IL1A, interleukin 1 alpha, 3552

N. diseases: 1002; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.330 Biomarker disease BEFREE When IL-1 signaling was blocked by recombinant IL-1 receptor antagonist, liver tumor formation and M2-type macrophages were reduced, suggesting that IL-1 signaling contributes to M2 polarization and tumor growth in NAFLD. 31044438 2019
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.330 AlteredExpression disease BEFREE Pathways responsible for the activation of IL-1 family cytokines are key in the development of NAFLD but underlying mechanisms are not fully understood. 29665983 2018
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.330 GeneticVariation disease BEFREE Major D allele of IL-1A (I/D) gene polymorphism is associated with NAFLD in the Egyptian population. 28627263 2017
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.330 Biomarker disease CTD_human Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease. 21664615 2011