|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated whether expression of xylosyltransferase-1 (XT-1), a key enzyme in glycosaminoglycan biosynthesis, is responsive to disk degeneration and to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus (NP) cells.
|
25476526 |
2015 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, AF cells were exposed to IL-1β, which was applied to mimic intervertebral disc degeneration (IDD) <i>in vitro</i>.
|
28123635 |
2017 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NLRP3/caspase-1/IL-1β axis is active in cartilaginous endplates of patients with Modic changes and inflammatory cascades can exacerbate the cartilaginous endplate degeneration which may act as a trigger for intervertebral disc degeneration and low back pain.
|
27146654 |
2016 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
This in vitro study has shown that the use of ex vivo gene transfer to degenerate disc tissue is a feasible therapy for the inhibition of IL-1-mediated events during disc degeneration.
|
16436110 |
2006 |
|
Intervertebral Disc Degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1β and hypoxia synergetically contributed to the catabolic effects of the nucleus pulposus cells by upregulating the expression of MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 through the activation of NF-κB signaling pathway, indicating that the NF-κB signaling pathway is a key mediator of intervertebral disc degeneration.
|
30468453 |
2018 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the role of IL-1 in driving age-related disc degeneration, we studied the spine phenotype of global IL-1α/β double knockout (IL-1KO) mice at 12 and 20 months.
|
30875127 |
2019 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The major inflammatory cytokine IL-1β is associated with intervertebral disc degeneration; however, the molecular mechanisms that drive IL-1β production in the intervertebral disc, especially in nucleus pulposus (NP) cells, are unknown.
|
28224704 |
2017 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-1β gene is currently topic of interest for its important role in the pathogenesis of intervertebral disk degeneration.
|
28296211 |
2017 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downregulation of IL-37 expression appeared to result in overexpression of pro-inflammatory cytokines, such as IL-1β and IL-16, in degenerative IVD and may be a contributor involved in the progression of IVDD.
|
24551286 |
2014 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results support the hypothesis that IL-1β and the p38 MAPK signal may be responsible for many of the inflammatory and catabolic changes seen in the human disk degeneration, and support our proposal that HBO treatment-induced increase of the anabolic factor (TIMP-1)/catabolic factor (MMP-3) ratio may provide a therapeutic approach to slow the course of intervertebral disk degeneration.
|
20661932 |
2011 |
|
Intervertebral Disc Degeneration
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, nucleus pulposus cells stimulated with interleukin-1β (IL-1β) expressed less SIRT3 than that in the control group and nucleus pulposus cells with SIRT3 overexpress vectors expressed more collagen II FOXO3a and superoxide dismutase 2 (SOD2), indicating that SIRT3 could improve the intervertebral disc degeneration by anti-oxidative stress.
|
31773668 |
2019 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.
|
26877238 |
2016 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation.
|
31772145 |
2019 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1β in its pathology.We therefore propose that <i>P. acnes</i> involvement in DDD is biologically very plausible, and that IL-1β is the key inflammatory mechanism driving the host response to <i>P. acnes</i> infection.
|
30155445 |
2018 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo.
|
30785069 |
2019 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Baicalein Inhibits the IL-1β-Induced Inflammatory Response in Nucleus Pulposus Cells and Attenuates Disc Degeneration In vivo.
|
30729381 |
2019 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mean percent area for IL-1ß (2.41 ± 0.66 versus 0.13 ± 0.13, p = 0.01), VEGF (3.02 ± 1.01 versus 0.34 ± 0.29, p = 0.04), and substance P (4.15 ± 1.01 versus 1.05 ± 0.46, p = 0.01) was also higher in TDR tissues when compared with disc tissues from patients with painful degenerative disc disease.
|
27488379 |
2017 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Potential therapeutic role of Co-Q10 in alleviating intervertebral disc degeneration and suppressing IL-1β-mediated inflammatory reaction in NP cells.
|
30261465 |
2018 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
To study the role of the interleukin-1 beta gene (IL1B) and the IL-1 receptor antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in the hip, knee, and hand and disc degeneration of the spine.
|
15077300 |
2004 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The gene expression profiles data were obtained using the same microarray platform for two groups of patients suffering from degenerative disc diseases: GSE41883 (Human annulus disc cells exposed to TNF-a; 4 samples) and GSE27494 (Human annulus disc cells exposed to IL-1β; 4 samples).
|
26200140 |
2018 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, in our present study we investigated the protective effects and potential mechanisms of wogonin in rat nucleus pulposus cells that had been treated with interleukin-1beta (IL-1β) to induce severe IVDD.
|
30412851 |
2018 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, mRNA and protein levels of known matrix components and of matrix degradation enzymes were determined to elucidate the function of miR-7 in IL-1β-induced disc degeneration.
|
27583982 |
2016 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 1 beta (IL-1β) is a major inflammatory factor that accelerates disk degeneration, and IL-1β levels increase in degenerative disks.
|
31427974 |
2019 |
|
Intervertebral Disc Degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
CircSEMA4B targets miR-431 modulating IL-1β-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway.
|
30251693 |
2018 |
|
Intervertebral Disc Degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-1 gene cluster polymorphisms could affect the risk of disc degeneration.
|
15308963 |
2004 |