|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Changes in MCP1, eotaxin, IL1β and PDGF-BB were observed in IR children with obesity.
|
30350467 |
2019 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
IL1B genetic variation may have a role in CRP level regulation and this association may be modified by obesity.
|
18573495 |
2009 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
This review will focus on the current understanding of the IL-1 superfamily of cytokines in the setting of obesity and discuss how endogenous feedback loops can be exploited for therapeutic approaches to fight obesity and subsequent cardiometabolic disorders.
|
27726910 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL1R1/IL1β augment both megakaryocyte and platelet functions, thereby promoting a prothrombotic environment during infection and obesity; potentially contributing to the development of atherothrombotic disease.
|
24458711 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-1β (IL-1β), a proinflammatory cytokine often elevated in obesity, is known to activate several procarcinogenic signaling pathways that are implicated in colonic carcinogenesis.
|
30328795 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In some tissues, advanced glycation end products (AGEs), which accumulate in NP tissues and promote its degeneration, increase oxidative stress and IL-1β secretion, resulting in disorders, such as obesity, diabetes mellitus and ageing.
|
28224704 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance.
|
27840174 |
2017 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our findings suggest that in a CHD population IL-1 gene polymorphisms may be involved in increased central obesity, and the genetic influences are more evident among patients who have a higher level of obesity or inflammatory markers.
|
18716798 |
2008 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
|
19808894 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, the association between interleukin-1beta (IL-1beta) and obesity remains controversial.
|
19398847 |
2009 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
IL-1 antagonism decreases cortisol levels in male patients with obesity and chronic low-grade inflammation on the short term.
|
31042669 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
It is not known to what extent inflammation precedes the development of obesity.MethodsIn a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age.ResultsAmong children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14.
|
29244802 |
2018 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the adipokine genes, LEP, LEPR, and RETN were not associated with obesity susceptibility, whereas ADIPOQ G276T (T vs. G: odds ratio (OR), 1.59; 95% confidence interval (CI), 1.39-1.81), IL-1β C3953T (CC vs. CT+TT: OR, 1.61; 95% CI, 1.18-2.20), and TNF-α G308A (GG vs. GA+AA: OR, 1.19; 95% CI, 1.02-1.39) polymorphisms were associated with an increased risk of obesity.
|
21660081 |
2012 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We used human adipose tissue biopsies to study the relationship of MAP3K8 expression with markers of obesity and expression of pro-inflammatory cytokines (IL-1β, IL-6 and IL-8).
|
24586913 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The allele 2 was observed in normal weight obese as well as a significant association between the increase of interleukin-1 beta plasma amount and the allele 2 carrier.
|
17174563 |
2007 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the development of systemic insulin resistance.
|
25182023 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined.
|
25526310 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.
|
24520123 |
2014 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
This framework may help identify novel approaches for promoting chondrocyte homeostasis during aging and obesity.<b>Materials and Methods</b>: Changes in glutathione content and redox ratio were evaluated in three models of chondrocyte stress: (1) age- and tissue-specific changes in joint tissues of 10 and 30-month old F344BN rats, including <i>ex vivo</i> patella culture experiments to evaluate N-acetylcysteine dependent resistance to interleukin-1beta; (2) effect of different durations and patterns of cyclic compressive loading in bovine cartilage on glutathione stress resistance and resilience pathways; (3) time-dependent changes in GSH:GSSG in primary chondrocytes from wild-type and Sirt3 deficient mice challenged with the pro-oxidant menadione.<b>Results</b>: Glutathione was more abundant in cartilage than meniscus or infrapatellar fat pad, although cartilage was also more susceptible to age-related glutathione oxidation.
|
31522568 |
2020 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Obese pigs had decreased cytokine levels (IL-1β, TNF-α, IL-4, IL-10), arachidonic acid and plasma insulin, but increased levels of vaccenic acid.
|
28704429 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-6 and IL-15 protein concentrations were higher in SAT than in VAT for both obese (p = 0.003 and p < 0.0001, respectively) and control individuals (p = 0.004 and p = 0.001, respectively), while for IL-1β this was observed only in obese subjects (p = 0.047).
|
26516848 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study corroborates the idea that the IL-1 system is linked to the development of obesity.
|
19666082 |
2010 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Members of the interleukin-1 (IL-1) family are important mediators of obesity and metabolic disease and have been described to often play opposing roles.
|
31488830 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Compared to non-treated tissues, PCA reduced phospho-p65 NF-κB and IL-6 in OB-VAT, and IL-1β in NW-VAT (p < 0.05); and increased adiponectin secretion in NW-VAT (p < 0.05).
|
29769704 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-1β is a pivotal inflammatory cytokine associated with obesity and pregnancy complications, and its production is regulated by NLR family pyrin domain-containing 3 (NLRP3) inflammasomes.
|
28515391 |
2017 |