|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This is particularly important given recent completed and ongoing clinical trials with IL-1 biologics that have had varying degrees of failure and success as therapeutics for disease modification in asthma and COPD.
|
31727692 |
2020 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Sputum eDNA in asthma was associated with airway neutrophilic inflammation, increases in soluble NET components, and increases in caspase 1 activity and IL-1β (all <i>P</i> values <0.001).
|
30888839 |
2019 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Higher relative abundance of these bacteria is furthermore associated with an airway immune profile dominated by reduced TNF-α and IL-1β and increased CCL2 and CCL17, which itself is an independent predictor for asthma.
|
31676759 |
2019 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-1 receptor-like 1 (IL1RL1) and thymic stromal lymphopoietin (TSLP) play important roles in asthma in various ways.
|
31066119 |
2019 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the NLRP3 inflammasome pathway with increased IL-1β has been demonstrated in various studies involving patients with asthma.
|
30422895 |
2019 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-1β and TNF-α, which are two key pro-inflammatory cytokines that mediate the correlation of depressive symptoms with impaired BDR and neutrophilic airway inflammation, may serve as targeted biomarkers in the neuropsychological phenotype of asthma; however, this result needs to be further validated.
|
30675924 |
2019 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, Th17 response cytokines IL-17 and IL-1β were only elevated in RV-C-infected children with pre-existing asthma.
|
31703379 |
2019 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A sputum gene expression signature of 6 biomarkers (6-gene signature [6GS], including Charcot-Leyden crystal galectin [CLC]; carboxypeptidase 3 [CPA3]; deoxyribonuclease 1-like 3 [DNASE1L3]; alkaline phosphatase, liver/bone/kidney [ALPL]; CXCR2; and IL1B) predicts inflammatory and treatment response phenotypes in patients with stable asthma.
|
30682452 |
2019 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we show that IL-1α and IL-1β are elevated in both bronchoalveolar lavage fluid and sputum from human asthmatics sensitized to fungi, implicating an association with IL-1α, IL-1β, or IL-1RA in fungal asthma severity.
|
31550242 |
2019 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the expression of IgE receptors fc epsilon RI, fc epsilon RII/CD23, and soluble CD23 (sCD23), and the activation state of peripheral blood monocytes (tumor necrosis factor alpha, interleukin (IL) 1-beta, transforming growth factor (TGF) beta expression) in the patients with severe asthma before and after 24 weeks of omalizumab treatment and in the healthy controls.
|
29279058 |
2018 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.
|
28528200 |
2018 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Body composition, asthma control, and the levels of IL-1β, -4, -13, leptin and adiponectin in obese asthmatics were significantly different from those in lean asthmatics.
|
30306746 |
2018 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-1 receptor appears to be a marker of neutrophilic inflammation and airflow obstruction in patients with asthma, who have a wide range of disease severity.
|
29103994 |
2018 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the roles and therapeutic targeting of the NLRP3 inflammasome and IL-1β in severe, steroid-resistant asthma.
|
28252317 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The NLRP3 inflammasome/caspase-1/IL-1β axis may be a therapeutic target in severe steroid-resistant asthma.
|
28356505 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, SMAD3 methylation in IIS neonates with maternal asthma was strongly and positively associated with neonatal production of IL-1β, an innate inflammatory mediator.
|
28011059 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In aged asthmatic patients increased sputum IL-6 and macrophage inflammatory protein 3α/CCL20 levels were significantly associated with decreased asthma control and increased sputum neutrophil numbers and IL-1β, IL-6, and macrophage inflammatory protein 3α/CCL20 levels were associated with hospitalization.
|
27725186 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We uncovered a critical role for the IL-1β pathway in patients with T<sub>H</sub>2/T<sub>H</sub>17-predminant asthma.
|
27702673 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results showed that Muc5ac and IL-1β were up-regulated in 41 patients with asthma and that Muc5ac overexpression was related with IL-1β in asthma (R<sup>2</sup>=0.668, p≪0.001).
|
29031476 |
2017 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interleukin 1β polymorphism and serum level are associated with pediatric asthma.
|
29034996 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstructive pulmonary disease (COPD).
|
28262817 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Titers and RNA of RV14 and cytokine concentrations, including IL-1β and IL-6, were higher in the supernatants of the cells obtained from subjects with bronchial asthma (asthmatic group) than in those from the non-asthmatic group.
|
28861755 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patients with co-morbid GAD and asthma showed higher sputum IL-1 AUC, sputum IL-6 AUC and sAA AUC.
|
28716529 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our study identifies caspase-8 as a master regulator of IL-1 cytokines that contribute to the pathogenesis of asthma and implicates caspase-8 inhibition as a potential therapeutic strategy for asthmatic patients.
|
27007676 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-37 a New IL-1 Family Member Emerges as a Key Suppressor of Asthma Mediated by Mast Cells.
|
27982737 |
2017 |