Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The hippocampus is particularly vulnerable to altered concentrations of the pro-inflammatory cytokine interleukin-1β (IL-1β), with elevated levels implicated in the aetiology of neurodegenerative disorders such as Alzheimer's and Parkinson's, and stress-related disorders such as depression.
|
31604142 |
2020 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the rat depression model, depression decreased tear secretion and increased IL-1β and TNF-α production, whereas the serotonin, TLR2, and TLR4 levels were not increased.
|
30695093 |
2019 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In all subjects, the IL-1β levels were correlated with PCL scores, after controlling for covariates, including age, education, marital status and gender, trauma exposure severity and depression.
|
30711869 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The biological link between depression, inflammation, and CVD can be related to high levels of pro-inflammatory cytokines, such as IL-1β, TNF-α, and IL-6, released by macrophages which play a central role in the pathophysiology of both depression and CVD.
|
31296155 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, mGluR5 deficiency dramatically inhibits cytokines release from bone marrow cells, such as IL-1β, TNF-α and IL-6, alleviating proinflammatory responses in LPS-induced depression model.
|
30682501 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since IL-1β and PGE<sub>2</sub> increase in serum of stressed patients and potentially trigger depression, we used an animal model of chronic unpredictable stress (CUS) to investigate the potential impact of LTB<sub>4</sub> over depression-like symptoms.
|
31057373 |
2019 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevations in brain interleukin-1 beta (IL-1β) during chronic stress exposure have been implicated in behavioral and cognitive impairments associated with depression and anxiety.
|
30711897 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-6 was elevated in DEP and DEP-T adolescents compared to controls (p = .014) and TNF-α was elevated in DEP participants only (p = .040) compared to controls, whereas no group differences were found in IL-1β (p = .829).
|
30978658 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Spearman's correlation analysis was used to analyze the correlation between PSQI, IL-1β and liver depression grade.
|
30651860 |
2019 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Then, alterations of pro-inflammation cytokine IL1-β level and microglia activity in the hypothalamus, which are involved in the pathophysiology of depression, were examined.
|
30703351 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The main findings of this study indicate a functional network in which several IL-1β-related molecules in CSF influence fatigue in addition to the classical clinical factors of depression and pain.
|
31101054 |
2019 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF levels were negatively correlated and IL-1β and TNF-α levels were positively correlated with Hamilton Depression Rating Scale-24 scores.
|
30616482 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the rat model and human cirrhosis a proinflammatory cytokine pattern (elevation of interferon gamma, interleukin [IL]-1β, IL-6) was registered which in humans correlated to the degree of HE and depression.
|
31170723 |
2019 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The logistic regression model and ROC curves based on serum levels of BDNF, IL-1β, and cortisol could distinguish depression from TDS in early stage, which could provide assistance to the differential diagnosis of geriatric depression and TDS.
|
29445283 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-alpha) was not related to depression.
|
29787856 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The hippocampus is particularly vulnerable to increases in the pro-inflammatory cytokine interleukin-1β (IL-1β), a mediator of neuroinflammation, with elevated levels implicated in the aetiology of neurodegenerative diseases such as Alzheimer's and Parkinson's, and in stress-related disorders such as depression.
|
30217534 |
2018 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Correlation analysis between HADS score and cytokine serum levels revealed positive associations of anxiety and/or depression with IL-1β, IL-6, IL-8, and TNF-α, and a negative correlation with IL-10, suggesting that cytokines are involved in the pathophysiology of these psychological disorders in CRC patients.
|
28969939 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared with controls, IL-1β (pooled standardized mean difference [SMD]: 0.642; 95% confidence interval [CI]: 0.078-1.206; significant heterogeneity: I<sup>2</sup> = 86.28%) and IL-6 (pooled SMD: 0.377; 95% CI: 0.156-0.598; significant heterogeneity: I<sup>2</sup> = 88.75%) were significantly elevated in depression.
|
30104698 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Incident depression was significantly associated with increases in IL-1β, IL-6, and IL-8 levels during the follow-up independent of relevant covariates and after applying Bonferroni corrections.
|
29471232 |
2018 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results of this study suggest that palmatine can alleviate the comorbidity of DNP and DP by inhibiting the expression of P2X<sub>7</sub> receptors in the hippocampus, and its action may be related to suppression of the phosphorylation of ERK1/2 and the release of TNF-α and IL-1β in the hippocampus.
|
29427595 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, the effects of chronic stress on both depression- and anxiety-like behaviors can be mimicked by exogenous intracerebroventricular (i.c.v.) administration of IL-1β in both WT and Caspase-1<sup>-/-</sup> mice.
|
28416811 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the IL-1 molecules are traditionally considered to be classical proinflammatory cytokines, their functions are not restricted to inflammation, and they have also been shown to play a key role in a wide range of additional physiological and pathological functions, including learning modulation, sleep, pregnancy, depression, appetite, hematopoiesis, metabolism, and many others.
|
29247999 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results of the present study suggested that AT-I exerts anti-depressant-like effects in a CUMS-induced model of depression in mice, the molecular mechanism of which is associated with the inhibition of NLRP3 inflammasome activation to decrease IL-1β production.
|
29434743 |
2018 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In recent years, proinflammatory cytokine interleukin-1β (IL-1β) was considered to play a critical role in the pathogenesis of depression.
|
28486969 |
2017 |