IL1B, interleukin 1 beta, 3553

N. diseases: 1801; N. variants: 22
Disease: Gastritis, Atrophic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease BEFREE The alleles IL-1β-31C and IL-1RN were associated with an increased risk of developing gastric carcinoma, and IL-1β-511T with an increased risk of developing chronic atrophic gastritis with no significant association of developing gastric carcinoma. 27340011 2016
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 AlteredExpression disease BEFREE Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice. 22079592 2012
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease BEFREE IL1B-1464-G/C genotype was associated with lower incidence of AG in corpus of the stomach in Asians [odds ratio: 0.7 (95% confidence interval=0.5-0.8); P=0.02]. 20631624 2010
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 Biomarker disease CTD_human Interleukin-1beta (IL-1beta) polymorphisms are associated with peptic ulcer and atrophic gastritis. 19448967 2009
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease BEFREE Interleukin-1beta (IL-1beta) polymorphisms are associated with peptic ulcer and atrophic gastritis. 19448967 2009
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease BEFREE The aim of this study was to evaluate the relationship between IL1B and IL1 receptor antagonist gene polymorphisms and the risk of multifocal atrophic gastritis in African Americans and Caucasians. 16405550 2006
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease LHGDN Possible association of interleukin 1B C-31T polymorphism among Helicobacter pylori seropositive Japanese Brazilians with susceptibility to atrophic gastritis. 15289894 2004
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease BEFREE Proinflammatory IL-1 polymorphisms (IL-1RN*2(+)/IL-1B-511T/-31C(+)) were associated with increased IL-1beta expression, more severe degrees of inflammation, and an increased prevalence of IM and AG. 15247172 2004
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease BEFREE We investigated the influence of bacterial virulence factors and host IL-1 polymorphisms on the development of histologic abnormalities in 210 Helicobacter pylori-infected patients with chronic gastritis. cagA(+)/vacAs1(+) H. pylori strains were associated with intestinal metaplasia (IM), atrophic gastritis (AG), and severe inflammation. 12854083 2003
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease BEFREE Proinflammatory IL-1beta polymorphisms are associated with hypochlorhydria and atrophic gastritis in Japan. 12105837 2002
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 GeneticVariation disease LHGDN Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. 12105837 2002
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.490 Biomarker disease HPO