Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The in vitro cell growth inhibitory activity of compounds <b>5</b>, <b>6</b>, <b>7</b>, <b>9</b>, and <b>10</b> was investigated in six human tumor cell lines: A375-C5 (malignant melanoma IL-1 insensitive), MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), U251 (glioblastoma astrocytoma), U373 (glioblastoma astrocytoma), and U87MG (glioblastoma astrocytoma).
|
29734739 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD133 Regulates IL-1β Signaling and Neutrophil Recruitment in Glioblastoma.
|
28736425 |
2017 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma microenvironment contains high levels of TNFα and IL-1β, which mediate inflammation through induction of a local network of cytokines and chemokines.
|
26794430 |
2016 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, elevated IL-1β levels in GBM tumours are also believed to activate GBM cells and enhance IL-6 production.
|
25088200 |
2015 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Biphasic effects of luteolin on interleukin-1β-induced cyclooxygenase-2 expression in glioblastoma cells.
|
25409926 |
2015 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The Proneural subgroup of the TCGA GBM patient dataset with high IL1β expression showed shorter survival compared to patients with low IL1β.
|
25987130 |
2015 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Specifically, the ability to produce IL-1 by glioblastoma cells may confer them a mesenchymal phenotype including increased migratory capacity, unique gene signature and proinflammatory signaling.
|
25054228 |
2014 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The secretion of IL-1β from glioblastoma cells in turn stimulates the expression of COX-2 in human or mouse neuroblastoma cells.
|
24621265 |
2014 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that when estimating the influence of IL-1β on the prognosis of glioblastoma patients, factors such as the degree of hypoxia, the expression levels of HIF-1 and AM should be taken into consideration.
|
24457964 |
2014 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma.
|
20865400 |
2011 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, our results suggest that SphK1 expression is transcriptionally regulated by IL-1 in glioblastoma cells, and this pathway may be important in regulating survival and invasiveness of glioblastoma cells.
|
19074142 |
2009 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these results indicate that S1P and IL-1 activate distinct pathways leading to the mRNA and protein expression of PAI-1 and uPAR, which are important for glioblastoma invasiveness.
|
18819934 |
2008 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines.
|
16356833 |
2006 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Northern blot analysis showed that treatment with interferon-gamma and with interleukin-1beta for 24 h decreased the expression levels of heme oxygenase-1 mRNA to approximately 20 and approximately 50% of the control levels, respectively, in a human glioblastoma cell line, T98G.
|
10349844 |
1999 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since malignant gliomas frequently show EGF receptor amplification and express IL-1, a pivotal regulatory cytokine involved in angiogenesis, we analyzed interactions between EGF/EGF receptor and IL-1/IL-1 receptor and VEGF in the established glioblastoma cell lines U-87 MG and A-172.
|
10571418 |
1999 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using RT-PCR, Northern blotting, and ELISA we demonstrated that the human U373 and U87 glioblastoma cell lines expressed IL-11 and its encoding mRNA when stimulated with IL-1 beta, phorbol ester, and calcium ionophore.
|
7501271 |
1995 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest a potential role of IL-1ra in regulation of the IL-1 autocrine loop in glioblastomas.
|
8120140 |
1994 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1).
|
8175759 |
1994 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, immunohistological analysis on fresh frozen tumour sections provided evidence for IL-1 production by glioblastoma cells in vivo.
|
8512018 |
1993 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha.
|
1937574 |
1991 |