Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Administration of human recombinant IL-1RA (Kineret/anakinra) during fungal-associated allergic airway inflammation improved airway hyperreactivity and lowered type 1 and type 17 responses.
|
31550242 |
2019 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, IL-1ra EBC concentrations were significantly lower in athletes than in HC, but again similar to asthmatics.
|
28822267 |
2018 |
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serum cytokine profiles with high levels of IL-1Ra and IL-10 were associated with lower subsequent risks of worsening asthma control and attacks in adults.
|
28340863 |
2017 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL-1RN(*)2 allele is a high risk factor for asthma in the studied North Indian population.
|
23602199 |
2013 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lung cancer risk also increased with the number of polymorphism sites where at least 1 'risk' allele was present [interleukin 1-β -31T/C (T allele), IL1RN (*2 allele) and IL6-634C/G (G allele)] among those with asthma, cough or atopy (Ptrend 0.001) but not in those without (Ptrend 0.47).
|
21252117 |
2011 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The allele and genotype frequencies of a number polymorphic genes coding for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 alpha, IL-1 beta, IL-1 receptor (IL-1R), IL-1RA, and IL-6 were investigated in 60 patients with asthma in comparison with 140 controls using polymerase chain reaction with sequence-specific primers.
|
18763028 |
2009 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Based on these results, we conclude that there was an association of pediatric asthma with the IL-1beta -511C/T and IL-1Ra intron 2 gene polymorphism.
|
18926055 |
2009 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL-6 and IL-1Ra polymorphisms can be considered genetic markers for bronchial asthma susceptibility and/or severity among Egyptian children.
|
18810365 |
2008 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In an unselected subset (n = 921) of the Isle of Wight birth (UK) cohort, which has previously been evaluated for asthma and related manifestations at ages 1, 2, 4 and 10 yrs, three IL1RN single nucleotide polymorphisms (SNP) were genotyped.
|
17107994 |
2007 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic variants of IL1RA gene do not to seem to affect asthma alone, but to act as modulators of asthma-related traits as well, where different haplotypes drive the development of different phenotypes.
|
16409203 |
2006 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Association of the interleukin-1 receptor antagonist gene with asthma.
|
15020290 |
2004 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the interleukin-1 receptor antagonist gene with asthma.
|
15020290 |
2004 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to test whether the polymorphisms of the promoter region and exon 5 of the IL-1 gene, intron 2 of the IL-1Ra gene, and -627 nucleotide (C/A) of the IL-10 gene could be genetic markers for the susceptibility of bronchial asthma.
|
12938145 |
2003 |
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The IL-1 Ra levels were significantly increased in black and white patients with severe or moderate asthma as compared to patients with mild asthma.
|
10843772 |
2000 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since Th1 and Th2 cytokines differentially regulate the ratio between IL-1beta and IL-1Ra, these findings suggest that dysregulation of IL-1beta/IL-1Ra, probably due to interaction between epithelium and immuno-competent cells in the airway, is important in asthma inflammation.
|
11027520 |
2000 |
Asthma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Effect of inhaled glucocorticoids on IL-1 beta and IL-1 receptor antagonist (IL-1 ra) expression in asthmatic bronchial epithelium.
|
9176529 |
1997 |