IL1RN, interleukin 1 receptor antagonist, 3557

N. diseases: 701; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Administration of human recombinant IL-1RA (Kineret/anakinra) during fungal-associated allergic airway inflammation improved airway hyperreactivity and lowered type 1 and type 17 responses. 31550242 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE In contrast, IL-1ra EBC concentrations were significantly lower in athletes than in HC, but again similar to asthmatics. 28822267 2018
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE Serum cytokine profiles with high levels of IL-1Ra and IL-10 were associated with lower subsequent risks of worsening asthma control and attacks in adults. 28340863 2017
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE IL-1RN(*)2 allele is a high risk factor for asthma in the studied North Indian population. 23602199 2013
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE Lung cancer risk also increased with the number of polymorphism sites where at least 1 'risk' allele was present [interleukin 1-β -31T/C (T allele), IL1RN (*2 allele) and IL6-634C/G (G allele)] among those with asthma, cough or atopy (Ptrend 0.001) but not in those without (Ptrend 0.47). 21252117 2011
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The allele and genotype frequencies of a number polymorphic genes coding for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 alpha, IL-1 beta, IL-1 receptor (IL-1R), IL-1RA, and IL-6 were investigated in 60 patients with asthma in comparison with 140 controls using polymerase chain reaction with sequence-specific primers. 18763028 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE Based on these results, we conclude that there was an association of pediatric asthma with the IL-1beta -511C/T and IL-1Ra intron 2 gene polymorphism. 18926055 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE IL-6 and IL-1Ra polymorphisms can be considered genetic markers for bronchial asthma susceptibility and/or severity among Egyptian children. 18810365 2008
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE In an unselected subset (n = 921) of the Isle of Wight birth (UK) cohort, which has previously been evaluated for asthma and related manifestations at ages 1, 2, 4 and 10 yrs, three IL1RN single nucleotide polymorphisms (SNP) were genotyped. 17107994 2007
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The genetic variants of IL1RA gene do not to seem to affect asthma alone, but to act as modulators of asthma-related traits as well, where different haplotypes drive the development of different phenotypes. 16409203 2006
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease LHGDN Association of the interleukin-1 receptor antagonist gene with asthma. 15020290 2004
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE Association of the interleukin-1 receptor antagonist gene with asthma. 15020290 2004
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The aim of this study was to test whether the polymorphisms of the promoter region and exon 5 of the IL-1 gene, intron 2 of the IL-1Ra gene, and -627 nucleotide (C/A) of the IL-10 gene could be genetic markers for the susceptibility of bronchial asthma. 12938145 2003
CUI: C0004096
Disease: Asthma
Asthma
0.400 AlteredExpression disease BEFREE The IL-1 Ra levels were significantly increased in black and white patients with severe or moderate asthma as compared to patients with mild asthma. 10843772 2000
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Since Th1 and Th2 cytokines differentially regulate the ratio between IL-1beta and IL-1Ra, these findings suggest that dysregulation of IL-1beta/IL-1Ra, probably due to interaction between epithelium and immuno-competent cells in the airway, is important in asthma inflammation. 11027520 2000
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease CTD_human Effect of inhaled glucocorticoids on IL-1 beta and IL-1 receptor antagonist (IL-1 ra) expression in asthmatic bronchial epithelium. 9176529 1997