IL1RN, interleukin 1 receptor antagonist, 3557

N. diseases: 701; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015967
Disease: Fever
Fever
0.560 Biomarker phenotype BEFREE IL-1Ra, CRP and procalcitonin were measured at the onset of fever (d0), on day 1 (d1) and on day 2 (d2). 30099772 2018
CUI: C0015967
Disease: Fever
Fever
0.560 AlteredExpression phenotype BEFREE Also, higher levels of IL-1ra were associated with subjects with arthralgia, whereas those with fever showed lower levels of granulocyte-colony stimulating factor (G-CSF). 29774022 2018
CUI: C0015967
Disease: Fever
Fever
0.560 AlteredExpression phenotype BEFREE Furthermore, the serum level of IL-1Ra was more increased in the febrile seizure group than in the same patients with only a fever. 29017522 2017
CUI: C0015967
Disease: Fever
Fever
0.560 Biomarker phenotype BEFREE Pro-inflammatory cytokines including TNF, IL-1alpha, IL-1beta and IL-1Ra cause systemic inflammatory reactions and numerous changes including altered cell signaling and migration, changes in cytokine production and fever. 19747989 2009
CUI: C0015967
Disease: Fever
Fever
0.560 Biomarker phenotype BEFREE In seizures, IL-1ra is a strong anticonvulsant and in IL-1beta-dependent fever, a powerful antipyretic. 17656565 2007
CUI: C0015967
Disease: Fever
Fever
0.560 Biomarker phenotype RGD One hundred femtomoles of ET-1 increased body temperature when injected in the POA of conscious Wistar rats; this effect was significantly counteracted by the coinjection of 600 pmol IL-1 receptor antagonist (IL-1ra). 16455768 2006
CUI: C0015967
Disease: Fever
Fever
0.560 Therapeutic phenotype CTD_human Beneficial response to anakinra and thalidomide in Schnitzler's syndrome. 16096327 2006
CUI: C0015967
Disease: Fever
Fever
0.560 Biomarker phenotype BEFREE IL-1 beta-induced fever can be blocked by IL-1ra pretreatment. 9629236 1998