Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-1RA has the potential to play a role in the treatment of gastric cancer.
|
29344744 |
2018 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Synergistic effect of H. pylori infection and IL-1B-511*T/IL-1RN*2 genotypes was also observed in association with significantly higher risk of developing GC.
|
28110439 |
2017 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The variant homozygote and heterozygote genotype of rs9005 in IL-1RN were significantly associated with increased risks of GC (ORadjusted [95%CI]: 1.71[1.04-2.81] and ORadjusted[95%CI]: 1.36 [1.04-1.78]).
|
26632693 |
2015 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this retrospective cohort study we genotyped 154 patients with gastric cancer for IL-1β and IL-1RN variations.
|
24557417 |
2015 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Haplotypes established from the three polymorphisms of IL-1RN were not associated with a risk of GC.
|
24080970 |
2014 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequency of IL-1RN alleles from patients with chronic gastritis and GC indicated that there was no difference between the genotypes of the groups studied.
|
22714811 |
2012 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
So, our results indicated that the IL-1RN*2 allele may increase the risk of gastric cancer and precancerous lesions in the Southeast Brazilian population, reinforcing the importance of host genetic factors in the susceptibility to gastric cancer and the participation of cytokines in both the inflammation and the carcinogenic process.
|
22327782 |
2012 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To investigate the associations between interleukin (IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet, Hui and Han ethnicities.
|
23323013 |
2012 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The data from the current study demonstrated that the genotype CC or CT of IL-1B-31, TT or CT of IL-1B-511, and 2L of IL-1RN increased risk of gastric cancer in this Chinese population and the risk was further enhanced by H. pylori.
|
21243433 |
2011 |
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
These cytokine gene polymorphisms, as well as those of IL-1B, IL-1RN and TNF-A, may be used to identify groups at higher risk of gastric cancer and peptic ulcer, and those suitable for their prevention by H. pylori eradication therapy in Western populations.
|
20222161 |
2010 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There was a statistical association between the presence of the IL-1RN*2 allele and gastric cancer (odds ratio 2.2, 95% confidence interval=1.2-3.7, P=0.01).
|
18779738 |
2009 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate that the IL-1B and IL-1RN polymorphisms are associated with the development of GC and H. pylori infection markedly increases the risk of GC in North Indian population.
|
19607807 |
2009 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Atrophic body gastritis patients harbouring the wild type of IL-1B-511/IL-1RN polymorphisms were not different from those harbouring the proinflammatory pattern as far as regards gender, age, gastric cancer family history and metaplastic atrophy.
|
18047563 |
2008 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The age-sex-adjusted odds ratios (OR) for the IL-1B-511 T genotype relative to the C/C genotype (OR = 0.82, 95% confidence interval [CI] 0.41-1.65), IL-1RN*2 genotype relative to the L/L genotype (OR = 0.85, 95% CI 0.41-1.78), and IL-2-330 T genotype relative to the G/G genotype (OR = 1.94, 95% CI 0.76-4.96) were not increased in GC.
|
18761558 |
2008 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multivariate regression analysis showed that cagE, babA2, and IL-1RN-1/2 genotypes were independent predictors of GC, but when patients with benign disorders were grouped together (NUD + DU) and compared with patients with GC, regression analysis disclosed that babA2 (P = 0.000) and IL-1B-31 gene polymorphisms (CC or CT) (P = 0.01) were the only independent markers of GC.
|
18807132 |
2008 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC.
|
18628242 |
2008 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL-1B-511T and IL-1RN *2 were associated with risks of gastric cancer.
|
18565646 |
2008 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IL-1B-511 and IL-1RN genetic polymorphisms are associated with an increased risk of developing gastric cancer.
|
17096351 |
2007 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A comprehensive analysis of 207 SNP of 11 cytokine genes revealed that variations in IL-4 and IL-1RN genes are negatively associated with the risk of developing gastric cancer following H. pylori infection.
|
17444864 |
2007 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Three hundred and ninety-nine patients with gastroduodenal diseases (129 chronic gastritis, 127 duodenal ulcer and 143 non-cardiac gastric cancer) and 264 healthy controls were genotyped for IL-1B-511 and IL-1RN gene polymorphisms by the PCR-RFLP method.
|
17295877 |
2007 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We aimed to test for associations between polymorphisms in IL1B (-31 and +3954), IL10-592 and IL1RN variable number of tandem repeats (VNTR) and risk of gastric cancer in a Mexican population.
|
16114018 |
2006 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There was an association between the presence of IL-1RN*2 allele and gastric cancer [odds ratio (OR) = 2.2, 95% confidence interval (CI) = 1.0-3.3, P = 0.04).
|
17235630 |
2006 |
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
For the associations between IL-1RN and gastric cancer, ORs (95% CIs) for *2/L versus LL and *2/*2 versus L/L were 1.15 (0.96-1.38) and 1.23 (0.79-1.92).
|
17035400 |
2006 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis.
|
16985030 |
2006 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population.
|
15540224 |
2005 |