Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker group BEFREE As animal model and preclinical studies have shown, the recombinant interleukin-1 receptor antagonist (IL-1RA) improves clinical outcomes after stroke. 30355103 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker group BEFREE These results strongly suggest that the attenuation of neuroinflammation mediated by endogenous IL-1ra is an important therapeutic mechanism of IV-hUMSCs for the treatment of stroke. 29650950 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker group BEFREE Our results indicated that IL-1RA-PEP could effectively penetrate the brain of MCAO rats, alleviated the cerebral ischemia reperfusion injury by inhibiting neuroinflammation and oxidative stress, showing a great clinical potential for stroke. 28602833 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker group BEFREE Overall, our data demonstrate that systemic administration of IL-1Ra improves outcome and promotes neurogenesis after experimental stroke, further highlighting the therapeutic potential of this clinically approved drug. 27856349 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker group BEFREE Neuroprotection is also achieved by therapeutic injection of IL-1Ra-producing bone marrow cells 30 min after stroke onset, additionally improving the functional outcome in two different stroke models. 26860727 2016
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group BEFREE A total of 21 studies from 19 publications including 5280 stroke patients and 5699 controls were included in this meta-analysis which detect whether IL-1α-889C/T, IL-1β-511C/T and IL-1 RN polymorphism were associated with stroke susceptibility. 25917615 2015
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker group BEFREE These data indicate that IL-1ra and IL1RN may influence the risk of infection after stroke, but this influence seems limited to infections other than pneumonia. 24233813 2014
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group BEFREE The unadjusted association model a, and the fully saturated model e, adjusted for age, gender, and stroke risk factors demonstrated no significant increase in risk associated with the IL1RN gene 2/2 genotype (a: OR, 1.11; 95% confidence interval [CI], .67-1.89; P=.615; and e: OR, .95; 95% CI, .46-1.94; P=.574). 24680088 2014
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 AlteredExpression group BEFREE Furthermore, increased plasma levels of interleukin-1 receptor antagonist were observed in the subtype of cryptogenic stroke compared with controls. 22744645 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group BEFREE We also reported a higher frequency in stroke subjects with a significant risk trend of the TPA 7351-CT genotype and of IL-1RN-VNTR 86 bp 2/2 genotype. 22425140 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group BEFREE A variable number of tandem repeats (VNTR) in intron 2 of the IL-1Ra gene was analyzed in 148 patients with stroke and 161 healthy volunteers from the same area. 19811433 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group BEFREE Patients with at least one copy of the IL1RN*2 allele had increased risk of death during the first week, and patients homozygotic for this allele had increased risk of death within the first month after stroke. 16980335 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group BEFREE The effect of allele 2 of IL1RN on stroke risk most closely fits a recessive genetic model (P=0.009). 17332449 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group LHGDN Allele 2 of IL1RN, present in nearly one-quarter of stroke patients, may contribute to genetic risk for ischemic stroke and confirm the previously identified association with cerebrovascular disease. 17332449 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group LHGDN Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. 16879054 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group BEFREE Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. 16879054 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group LHGDN Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene. 15036607 2004
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 GeneticVariation group BEFREE As expected, the estimated frequency of the IL-1Ra allele 1 (Ra*1 allele) in stroke survivors was higher than in age-matched controls (0.851 and 0.664, respectively; p < 0.001) and in healthy Italians (0.851 and 0.717, respectively; p < 0.001). 12686792 2003
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 Biomarker group CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.400 AlteredExpression group BEFREE Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. 7790404 1995