Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
As animal model and preclinical studies have shown, the recombinant interleukin-1 receptor antagonist (IL-1RA) improves clinical outcomes after stroke.
|
30355103 |
2018 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
These results strongly suggest that the attenuation of neuroinflammation mediated by endogenous IL-1ra is an important therapeutic mechanism of IV-hUMSCs for the treatment of stroke.
|
29650950 |
2018 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Our results indicated that IL-1RA-PEP could effectively penetrate the brain of MCAO rats, alleviated the cerebral ischemia reperfusion injury by inhibiting neuroinflammation and oxidative stress, showing a great clinical potential for stroke.
|
28602833 |
2017 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Overall, our data demonstrate that systemic administration of IL-1Ra improves outcome and promotes neurogenesis after experimental stroke, further highlighting the therapeutic potential of this clinically approved drug.
|
27856349 |
2017 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Neuroprotection is also achieved by therapeutic injection of IL-1Ra-producing bone marrow cells 30 min after stroke onset, additionally improving the functional outcome in two different stroke models.
|
26860727 |
2016 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A total of 21 studies from 19 publications including 5280 stroke patients and 5699 controls were included in this meta-analysis which detect whether IL-1α-889C/T, IL-1β-511C/T and IL-1 RN polymorphism were associated with stroke susceptibility.
|
25917615 |
2015 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
These data indicate that IL-1ra and IL1RN may influence the risk of infection after stroke, but this influence seems limited to infections other than pneumonia.
|
24233813 |
2014 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The unadjusted association model a, and the fully saturated model e, adjusted for age, gender, and stroke risk factors demonstrated no significant increase in risk associated with the IL1RN gene 2/2 genotype (a: OR, 1.11; 95% confidence interval [CI], .67-1.89; P=.615; and e: OR, .95; 95% CI, .46-1.94; P=.574).
|
24680088 |
2014 |
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Furthermore, increased plasma levels of interleukin-1 receptor antagonist were observed in the subtype of cryptogenic stroke compared with controls.
|
22744645 |
2012 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We also reported a higher frequency in stroke subjects with a significant risk trend of the TPA 7351-CT genotype and of IL-1RN-VNTR 86 bp 2/2 genotype.
|
22425140 |
2012 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A variable number of tandem repeats (VNTR) in intron 2 of the IL-1Ra gene was analyzed in 148 patients with stroke and 161 healthy volunteers from the same area.
|
19811433 |
2009 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Patients with at least one copy of the IL1RN*2 allele had increased risk of death during the first week, and patients homozygotic for this allele had increased risk of death within the first month after stroke.
|
16980335 |
2007 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The effect of allele 2 of IL1RN on stroke risk most closely fits a recessive genetic model (P=0.009).
|
17332449 |
2007 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Allele 2 of IL1RN, present in nearly one-quarter of stroke patients, may contribute to genetic risk for ischemic stroke and confirm the previously identified association with cerebrovascular disease.
|
17332449 |
2007 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
|
16879054 |
2006 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
|
16879054 |
2006 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene.
|
15036607 |
2004 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As expected, the estimated frequency of the IL-1Ra allele 1 (Ra*1 allele) in stroke survivors was higher than in age-matched controls (0.851 and 0.664, respectively; p < 0.001) and in healthy Italians (0.851 and 0.717, respectively; p < 0.001).
|
12686792 |
2003 |
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
CTD_human |
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.
|
12374626 |
2002 |
Cerebrovascular accident
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain.
|
7790404 |
1995 |