|
Arthritis, Infectious
|
0.010 |
Biomarker
|
group |
BEFREE |
Impact of simultaneous neutralization of IL-17A and treatment with recombinant IL-2 on Th17-Treg cell population in S.aureus induced septic arthritis.
|
31790794 |
2020 |
|
Corneal dystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Significant higher level of IL-2 was observed in both epithelial and stromal CD.
|
31756391 |
2020 |
|
Dengue Fever
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IL-2, TNF-<i>α</i>, IL-4, and IL-10 levels were significantly elevated (<i>p</i> < 0.005) in patients with secondary DENV infection, whereas the level of IL-13 remained unaltered during both primary and secondary infections.
|
31532346 |
2020 |
|
Nausea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Interleukin-2 was elevated after gluten in 97% of patients (median fold-change: 20), and correlated with severity of nausea (r<sub>s</sub> = .49, P = .0025) and occurrence of vomiting (P = .0005).
|
31769533 |
2020 |
|
Vomiting
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Interleukin-2 was elevated after gluten in 97% of patients (median fold-change: 20), and correlated with severity of nausea (r<sub>s</sub> = .49, P = .0025) and occurrence of vomiting (P = .0005).
|
31769533 |
2020 |
|
Arthritis, Bacterial
|
0.010 |
Biomarker
|
group |
BEFREE |
Impact of simultaneous neutralization of IL-17A and treatment with recombinant IL-2 on Th17-Treg cell population in S.aureus induced septic arthritis.
|
31790794 |
2020 |
|
Aplastic Anemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among these patients, the IL-2 levels were higher in patients with Very Severe Aplastic Anaemia (VSAA) and Severe Aplastic Anaemia (SAA) than those with Non-severe Aplastic Anaemia (NSAA) in the PBP (65.6 ± 23.61 vs. 31.72 ± 7.64; p-value 0.00338) and (45.37 ± 16.25 vs. 31.72 ± 7.64; p-value 0.01468) respectively.
|
30139310 |
2019 |
|
Aortic Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Considerably increased levels of IL-2 were found in the PBP and BMP of AAA patients as compared to controls (48.54 ± 21.89 vs. 1.99 ± 1.25 p-value < 0.00001) and (75.33 ± 41.9 vs. 3.12 ± 1.82; p-value < 0.00001) respectively.
|
30139310 |
2019 |
|
Appendicitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-2 and D-dimer values were higher in the groups diagnosed with appendicitis but were not statistically significant.
|
31290753 |
2019 |
|
Cerebral Palsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, in CP-treated rats, PGE treatment induced the recovery of white blood cell, neutrophil, and lymphocyte counts, along with mid-range absolute counts, and increased the serum levels of inflammatory cytokines (TNF-α, IFN-γ, IL-2, and IL-12) and immunoglobulins (IgG and IgA).
|
31752816 |
2019 |
|
Chronic osteomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-2/STAT5/CD4+CD25+Foxp3 Treg pathway may be involved in the pathogenesis of COM, and excessive immunosuppression may lead to persistent infectious inflammation, which may become a key target for future treatment of COM.
|
31555698 |
2019 |
|
Patent ductus arteriosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
We report that treatment with a novel antibody against tMUC1 in combination with a unique formulation of IL-2 can improve survival and lead to stable disease in appropriate models of PDA by reducing tumor-induced immune regulation and promoting recruitment of CD45+CD11b+ cells, thereby enhancing ADCC/ADCP.
|
31114758 |
2019 |
|
Eating Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
IL-2 increase was not linked to EDs, but to the interaction of depression and BMI.
|
31450770 |
2019 |
|
Endometrial Hyperplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Melatonin administration reduced estradiol benzoate-induced endometrial hyperplasia and prevented the occurrence of atypia associated with a significant reduction in lipid peroxide level and NF-κB mRNA and a significant rise in immune-expression of caspase-3, interleukin-2 (IL-2) mRNA and total antioxidant levels in uterine tissues.
|
30657459 |
2019 |
|
Epidermodysplasia Verruciformis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma.
|
30778533 |
2019 |
|
Exanthema
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
However, we demonstrated an association between the SNP in IL2 (rs2069762) and the onset of skin rash (P = 0·0001).
|
30203425 |
2019 |
|
Flushing
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
<b>Material and Methods</b> In this case control study, after obtaining endometrial flushing fluids at mid-luteal phase of ovulatory women with PCOS (n = 20), endometrioma (n = 19), leiomyoma (n = 20) and healthy controls (n = 20), IL-2 and TNF-α levels were measured using ELISA kits in BioTek ELISA devices.
|
31148852 |
2019 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, when pretreating ex vivo peripheral blood mononuclear cells of patients with CHF with RvD1 or RvD2, we found that neither of them was able to modulate the immune response of CD8<sup>+</sup> and CD4<sup>+</sup> T cells in terms of proinflammatory cytokine production, namely TNF-α, IFN-γ, IL-17, and IL-2.
|
30052486 |
2019 |
|
Hyperemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
And reduce the degree of edema and hyperaemia around the ulcer tissue significantly (<i>P</i> < 0.01), improve the ulcer healing probability, and reduce the level of TNF-α, VEGF levels and increase IL-2 level in the serum of rats with oral ulcers significantly (<i>P</i> < 0.01).
|
31049005 |
2019 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Mean arterial pressure was significantly lower in IL-2-treated SLE mice compared with vehicle-treated SLE mice, suggesting that expanding T<sub>REG</sub> cells using low-dose IL-2 attenuates the development of hypertension.
|
30892934 |
2019 |
|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequently, expression of tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), and IL-6 were detected to further determine the effects of miR-181c-5p and IL1A on inflammation in IBS. miR-181c-5p and IL1A might be involved in IBS. miR-181c-5p was found to be decreased while IL1A was increased in IBS rats.
|
31172560 |
2019 |
|
Lymphadenitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mycobacterium avium lysate IL-2 and INF-γ-based enzyme-linked immunospot assays seem to be promising noninvasive diagnostic techniques for discriminating children with nontuberculous mycobacteria lymphadenitis and noninfected subjects.
|
30834995 |
2019 |
|
Mycobacterium avium-intracellulare Infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with MAC-LD generally had lower total IFN-γ+, total TNF-α+ and triple-positive T cells but higher mono-IL-2+ expression than the controls and MAC-Co group.
|
31085455 |
2019 |
|
Mycoses
|
0.010 |
Biomarker
|
group |
BEFREE |
The levels of antibodies, including IgM and IgA, cytokines, including IL-2, IL-6, and macrophage colony-stimulating factor (M-CSF), and soluble CD4 and CD8 in the serum of the FI group vs. the control group were determined independently.
|
31579583 |
2019 |
|
Myositis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At the onset of myositis, the patient lost lower limb mobility against gravity, and had an activated immune profile with increased cytotoxic CD107a and granzyme B expression, as well as pro-inflammatory cytokines, interferon-γ, tumor necrosis factor-α, interleukin-2 in T and NK cells compared to healthy donor.
|
30604316 |
2019 |