IL2, interleukin 2, 3558

N. diseases: 950; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group BEFREE The results showed that rNDV-IL2-NP/P had the strongest inhibition of murine hepatoma carcinoma tumors. 27736965 2016
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group BEFREE Adeno-associated viral-mediated gene transfer to hepatoma: thymidine kinase/interleukin 2 is more effective in tumor killing in non-ganciclovir (GCV)-treated than in GCV-treated animals. 10933975 2000
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group BEFREE In conclusion, the Anhinga strain could be an effective vector for tumor therapy; the recombinant NDV/Anh-IL-2 strain expressing soluble IL-2 is a promising candidate for hepatoma therapy. 27174862 2016
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group BEFREE IL-2 transduction into the hepatoma cells resulted in increased antigenicity to the tumors formed by IL-2 transduced hepatoma cell line and parent cell line, which leads the regression of the tumors. 9864400 1999
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group BEFREE Animal studies showed that rClone30-interleukin-12-interleukin-2 was more effective in inhibition of murine hepatoma carcinoma tumors, with the mean tumor volume (day 14) of 141.70 mm(3) comparing 165.67 mm(3) of rClone30-interleukin-12 group, 210.47 mm(3) of rClone30-interleukin-2 group, 574.70 mm(3) of rClone30 group, and 1206.83 mm(3) of phosphate-buffered saline group. 26303327 2016
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Therapeutic group CTD_human Low-dose cyclophosphamide and continuous-infusion interleukin-2 with famotidine in previously treated metastatic melanoma or kidney cancer. 18298334 2008
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 AlteredExpression group BEFREE IL-2 and/or IL-12 genes injected directly into spleen increase serum IL-2 and IL-12 levels and enhance the NK cell activity, which may inhibit the liver tumor growth. 15259063 2004