IL2, interleukin 2, 3558

N. diseases: 950; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 Biomarker disease BEFREE The ability of IL‑2 to stimulate immunoregulation and the ability of p53 to induce apoptosis for GBM was researched in the GBM tumor model. 29328445 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 Biomarker disease BEFREE HSV-TK/IL-2 gene therapy for glioblastoma multiforme. 19565921 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 Biomarker disease BEFREE Reverse transcription-polymerase chain reaction (RT-PCR) analysis for interleukin 4 receptor alpha (IL-4Ralpha), interleukin 13 receptor alpha1 (IL-13Ralpha1), interleukin 2 receptor gammac (IL-2Rgammac) were performed on total RNA extracted from 10 non-invasive pituitary adenomas, 30 invasive pituitary adenomas, one glioblastoma multiforme, one normal human pituitary tissue sample and one normal human brain tissue sample. 17398005 2007
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 Biomarker disease BEFREE Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: biological and clinical results. 15891772 2005
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 AlteredExpression disease BEFREE Glioblastoma cell lines transduced with this vector could produce high levels of IL-2 for up to 2 weeks, long enough to elicit an antitumor immune response. 10066092 1998
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 Biomarker disease BEFREE Four patients affected by glioblastoma recurrence were treated with a gene therapy-immunotherapy protocol consisting of intratumoral injections of culture cells producing a retroviral vector which expresses human interleukin-2 and the herpes simplex virus thymidine kinase genes. 9711724 1997
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 Therapeutic disease CTD_human These results support the evaluation of this form of IL-2 gene therapy in additional patients with glioblastoma. 7719933 1995
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 GeneticVariation disease BEFREE These results support the evaluation of this form of IL-2 gene therapy in additional patients with glioblastoma. 7719933 1995
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.380 Biomarker disease BEFREE T cell suppressor factor produced by human glioblastoma cells inhibits T cell proliferation in vitro and more specifically interferes with interleukin-2 (IL-2)-dependent T cell growth. 3497030 1987