Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
T-LGLL and ATL share dependence on IL-2 and IL-15 for survival and both diseases lack effective therapies.
|
30353031 |
2019 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
BAY 1143572-treated ATL-bearing mice (once daily 12.5 mg/kg oral application) demonstrated significantly decreased ATL cell infiltration of the liver and bone marrow, as well as decreased human soluble interleukin-2 receptor levels in serum (reflecting the ATL tumor burden), compared with untreated mice (n = 8 for both).
|
28646117 |
2017 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, by using IL-2-dependent HTLV-1-infected T-cell lines (ILTs) established from patients with ATL and HAM/TSP, we demonstrate that the anti-inflammatory cytokine IL-10 and its downstream signals potentially act as a switch for proliferation in HTLV-1-infected cells.
|
28910419 |
2017 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Transforming activity was further demonstrated by the ability of the FBXW7 D510E mutant to provide IL-2-independent growth of Tax-immortalized human T cells and increase the tumor formation in a xenograft mouse model of ATL.
|
27247421 |
2016 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.
|
26396258 |
2015 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax.
|
25175936 |
2014 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
"The combination of arsenic, interferon-alpha, and zidovudine restores an ""immunocompetent-like"" cytokine expression profile in patients with adult T-cell leukemia lymphoma."
|
23962110 |
2013 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth.
|
22010857 |
2012 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These signaling proteins represent novel and promising molecular therapeutic targets for IL-2-dependent ATL.
|
22402124 |
2012 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abnormal IL-2Rα chain expression and the IL-2 dependency of ATL cell lines greatly contributed to the study of leukemogenesis of ATL.
|
22068231 |
2011 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This suggests the existence of compensatory mechanisms in IL-2-dependent cells and ATLL patients.
|
18511807 |
2008 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated that withdrawal of interleukin (IL)-2 from IL-2-dependent ATL cell lines resulted in induction of HTLV-1 mRNA and protein expression, and that viral induction was associated with phosphorylation of the stress kinase p38 and its downstream CREB.
|
17950728 |
2007 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
HTLV-I transformed T-cell lines and fresh ATL cells are characterized by constitutive activation of the interleukin-2 receptor (IL-2R) signaling pathway however, the mechanism(s) responsible for constitutive IL-2R activation are unknown.
|
14630083 |
2004 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells.
|
11992406 |
2002 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that interleukin 2 (IL-2) autocrine/paracrine growth in adult T-cell leukaemia (ATL) cells was closely correlated with clinical aggressiveness.
|
12406087 |
2002 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we report that IL-2-dependent ATL cell lines also express IL-4Ralpha and respond to IL-4, which was verified by the activation of cytoplasmic transcriptional activator Stat6 protein.
|
12225394 |
2002 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, novel treatments, such as monoclonal antibodies directed at the interleukin-2 receptor and the combination of interferon alfa and zidovudine, have been shown to be active in the treatment of patients with ATL.
|
12057109 |
2001 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings indicate that Gfi-1 activation is involved in the IL-2-independent growth of HTLV-I-transformed T cells in vitro and in the development of ATLL in vivo, but is not induced by STAT activation.
|
11503967 |
2001 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
High rate of chromosomal abnormalities in HTLV-I-infected T-cell colonies derived from prodromal phase of adult T-cell leukemia: a study of IL-2-stimulated colony formation in methylcellulose.
|
9973953 |
1999 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human thioredoxin (hTRX)/adult T-cell leukemia (ATL)-derived factor (ADF) was originally reported as an interleukin-2 (IL-2) receptor-alpha-inducing factor produced by human T-cell lymphotropic virus-1-positive (HTLV-1+) cell lines.
|
11228744 |
1999 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alteration of p16 (CDKN2) gene is associated with interleukin-2-induced tumor cell growth in adult T-cell leukemia.
|
10378889 |
1999 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Adult T cell leukemia (ATL) is an aggressive malignancy that is associated with HTLV-I infection and characterized by constitutive expression of the high-affinity interleukin-2 receptor.
|
9356333 |
1997 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Analysis of RNA from HTLV-I-infected cells established from patients with adult T cell leukemia (ATL) as well as tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) and both IL-2-dependent and IL-2-independent HTLV-I-infected cell lines by RNase protection has confirmed the existence of all of the alternatively spliced messages in each cell line analyzed.
|
9177442 |
1997 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We could not detect human T cell leukemia virus type I (HTLV-I) mRNA or interleukin 2 (IL-2) mRNA in either the tumor cells growing in mice or the original leukemic cells.
|
8878449 |
1996 |
Adult T-Cell Lymphoma/Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that malignant growth of primary tumor cells in lymph nodes may be associated with the IL-2-IL-2 receptor system in patients with ATL more frequently than had been previously thought.
|
8628012 |
1996 |