Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the study confirms the association of the IL2RA locus with T1D in the Polish population.
|
22211793 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Children of parents with type 1 diabetes and prospectively followed from birth for the development of islet autoantibodies and diabetes were genotyped for single-nucleotide polymorphisms at 12 type 1 diabetes susceptibility genes (ERBB3, PTPN2, IFIH1, PTPN22, KIAA0350, CD25, CTLA4, SH2B3, IL2, IL18RAP, IL10 and COBL).
|
22932816 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One is within the IL2RA gene for association with type 1 diabetes and the other in proximity with the CDKN2B gene for association with type 2 diabetes.
|
22293688 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here we apply PWAS ("proteome-wide analysis of SNPs"), a methodology based on quantitative mass spectrometry that enables rapid screening of SNPs for differential transcription factor binding, to 12 SNPs that are highly associated with type 1 diabetes at the IL2RA locus, encoding the interleukin-2 receptor CD25.
|
23028375 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interestingly, cesarean section appeared to interact with immune response genes, including CD25 and in particular the interferon-induced helicase 1 gene, where increased risk for type 1 diabetes was only seen in children who were delivered by cesarean section and had type 1 diabetes-susceptible IFIH1 genotypes (12-year risk, 9.1 vs. <3% for all other combinations; P < 0.0001).
|
22110093 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previous studies suggested the association of interleukin-2 (IL2) gene polymorphisms and its alpha- and beta-chain receptor (IL2RA and IL2RB) variants with different autoimmune diseases such as T1D, celiac disease, multiple sclerosis, and rheumatoid arthritis.
|
21875375 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
PTPN22 (1p13.2), STAT4 (2q32.2), CTLA4 (2q33.2), HLA (6p21), IL2RA (10p15.1), INS (11p15.5), ERBB3 (12q13.2), SH2B3 (12q24.12), and CLEC16A (16p13.13) were convincingly associated with autoimmune diabetes in adults (P ≤ 0.002), with consistent directions of effect as reported for pediatric type 1 diabetes.
|
21873553 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our observations confirm the presence of mRNA for pro- and anti-inflammatory cytokines in CD4+CD25+CD127dim/- cells in the peripheral blood of children with T1DM.
|
20529823 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
In conclusion, IL-2RA/CD25 is associated with type 1 diabetes in the Belgian population, independently of disease phenotype and other biologic markers.
|
20849903 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previous investigations have also demonstrated that two intronic SNPs (rs706778 and rs3118470) in the interleukin-2 receptor-alpha (IL2RA) gene were associated with type 1 diabetes in the Japanese population.
|
20615141 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.
|
20033399 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
We further show that the inhibitory function is due to the induction of TGF-beta-producing CD4(+)CD25(-) islet-specific iTreg cells against the onset of T1D in NOD mice.
|
19788384 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, IL2RA genetic variants correlate with the levels of a soluble form of the IL-2 receptor in subjects with type 1 diabetes and multiple sclerosis.
|
19155502 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
CTD_human |
Here, we report "allelic heterogeneity" at the IL2RA region between MS and T1D.
|
19119414 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lower IL2RA levels consistently originated from the T1D predisposing allele.
|
19794070 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
These findings confirm and extend the association of this gene with MS and reveal a genetic heterogeneity of the associated polymorphisms and risk alleles between MS and T1D suggesting different immunopathological roles of IL2RA in these two diseases.
|
19125193 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
The percentages of CD4(+)CD25(high)CD127(dim/-) were very low and did not differ between T1DM and control children.
|
19547759 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS).
|
19116909 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We show that SLE is associated with rs11594656 (P = 3.87 x 10-7) and there is some evidence of association of rs41295061 with AAV (P = 0.0122), which both have prior association with T1D. rs2104286, an MS and T1D - associated SNP in the IL2RA locus, is not associated with either SLE or AAV.
|
19265545 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our study shows an association of HLA DQB1 genotypes with CD4+CD25+(high) T-cell apoptosis, which implicates CD4+CD25+(high) T-cell apoptosis as a new intermediate trait for T1D.
|
19295543 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here, we summarize what we know about the genetics of T1D with an emphasis on the contributions of mouse Il2 and human IL2RA polymorphisms and the IL-2-IL-2R pathway to autoimmunity and, more specifically, Treg development and function.
|
19447046 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
CTD_human |
Here we use polychromatic flow cytometry to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA, or CD25) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region that have previously been associated with two autoimmune diseases, type 1 diabetes (T1D) and multiple sclerosis.
|
19701192 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
The present data confirm the type 1 diabetes association with IL2RA and provide evidence that the different contributions of the IL2RA in the susceptibility to acute-onset and other forms of type 1 diabetes in the Japanese population.
|
19106270 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here we use polychromatic flow cytometry to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA, or CD25) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region that have previously been associated with two autoimmune diseases, type 1 diabetes (T1D) and multiple sclerosis.
|
19701192 |
2009 |