Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This finding indicates that the inherited altered genetic constitution at IL2RA may predispose to a less destructive course of RA.
|
31134763 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In contrast, both antibodies induced early and sustained suppression of RA disease markers, including interleukin (IL)-6, C-reactive protein, IL2RA, and matrix metalloproteinase 1, in DMARD-IR patients.
|
30358109 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
RESULTS Compared with the healthy controls, the proportions of CD3+CD4+ T cells and CD3+CD4+CD25+CD127low T cells in the peripheral blood were significantly higher in RA patients.
|
30106887 |
2018 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
It was observed that in peripheral blood, CD4+CD25-FOXP3+/CD4+ levels were reduced in the RA group (P<0.001), and sPD‑1 levels were markedly higher (P<0.001), compared with the HC group.
|
27909722 |
2017 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg Cells in Patients With Chronic Rheumatoid Arthritis.
|
26314565 |
2016 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Targeted exon sequencing identified rare variants in IL2RA and IL2RB associated with rheumatoid arthritis.
|
27224741 |
2016 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This underlines the relevance of IL2RA for RA.
|
26350950 |
2015 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
|
24449572 |
2014 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated that the frequencies of CD3(+) CD4(+) IL-17(+) Th17 cells were significantly higher, and CD4(+) CD25(+) FOXP3(+) Treg cells significantly lower in peripheral blood mononuclear cells from RA patients.
|
25164131 |
2014 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
|
24449572 |
2014 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we have used a microarray approach to comprehensively analyze miRNA expression signatures of both naive Tregs (CD4+CD45RO-CD25++) and memory Tregs (CD4+CD45RO+CD25+++), as well as conventional naive (CD4+CD45RO-CD25-) and memory (CD4+CD45RO+CD25-) T cells (Tconvs) derived from peripheral blood of RA patients and matched healthy controls.
|
24401767 |
2014 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed an accumulation of rare nonsynonymous variants exclusive to RA cases in IL2RA and IL2RB (burden test: p = 0.007 and p = 0.018, respectively).
|
23261300 |
2013 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present genetic and serologic data suggest that inherited altered genetic constitution at the IL2RA locus may predispose to a less destructive course of RA.
|
23529819 |
2013 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
DNA microarray analysis of peripheral blood lymphocytes showed significant increase of interleukin (IL)-2 receptor α-chain (CD25) gene expression, a regulatory T cell (Treg) surface marker in severe RA patients.
|
21670968 |
2012 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, replicated associations of HLA-DRB1, PTPN22 (which confer ∼50% of the heritable risk to RA) and IL2RA suggest that cross-ethnicity fine mapping of such loci is apposite for identification of causal variants.
|
22355377 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The present study provides the first evidence of increased CD25(-)FOXP3(+) cells in RA patients, which were associated with disease activity and with GC treatment in carriers of the high IL-10 genotype, suggesting that this population plays a role in the clinical response to prednisone in RA.
|
22447883 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) are involved in several autoimmune diseases, including rheumatoid arthritis.
|
21346237 |
2011 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
TRAIL is associated with impaired regulation of CD4+CD25- T cells by regulatory T cells in patients with rheumatoid arthritis.
|
21732015 |
2011 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previous studies suggested the association of interleukin-2 (IL2) gene polymorphisms and its alpha- and beta-chain receptor (IL2RA and IL2RB) variants with different autoimmune diseases such as T1D, celiac disease, multiple sclerosis, and rheumatoid arthritis.
|
21875375 |
2011 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
We observed an increased expression of full-length FoxP3 mRNA in RA patients when compared to healthy controls, as well as an increase in CD25 mRNA expression, but no corresponding increase in CTLA-4 mRNA expression.
|
20476861 |
2010 |