|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Changes in CD4+CD25+FoxP3+ Regulatory T Cells and Serum Cytokines in Sublingual and Subcutaneous Immunotherapy in Allergic Rhinitis with or without Asthma.
|
31722337 |
2020 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The pathogenesis of asthma is dependent on the balance between regulatory and effector T cells, which display differential expression of CD25 and CD26.
|
29297467 |
2019 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, adoptive transfer of iTreg cells prevented disease in a CD25-depleted mouse asthma model.
|
29225189 |
2018 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The frequency and numbers of peripheral blood CD4+ interferon (IFN) gamma+ T-helper (Th) type 1, CD4+ IL-4+ Th2, CD4+ IL-17A+ Th17, CD4+CD25+ Forkhead Box P3+ regulatory T cells (Treg) and CD19+ IL-10+ Bregs in 22 children with asthma, 17 children with asthma and AR, and 25 healthy controls were determined by flow cytometry.
|
29046188 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Budesonide was able to increase the expression of TLR4, TLR2 and IL-10 in CD4+/CD25 highly+ cells from asthmatics.
|
25722071 |
2015 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms with suggestive evidence for association with asthma with hay fever risk included rs41295115 near IL2RA (OR, 1.28; P = 5 × 10(-7)) and rs76043829 in TNS1 (OR, 1.23; P = 2 × 10(-6)).
|
24388013 |
2014 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD4(+) CD25(+) CD127(-/low) T(regs) from participants without asthma did not elicit Ca(2+) influx in response to TCR activation, exhibited little proliferation and suppressed proliferation of CD4(+) CD25(-) T cells.
|
25048599 |
2014 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with healthy donors and patients with mild asthma, the percent of CD4+CD25+ Treg cells and plasma IL-10 levels were decreased in patients with moderate to severe asthma.
|
23786933 |
2013 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The proportion of CD45RO(+) cells in CD4(+)CD25(+) (high + low) T cells from pediatric asthma was much smaller (about 56%).
|
21576985 |
2011 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To evaluate main effects and gene-gene interactions of haplotype tagging single nucleotide polymorphisms of genes involved in regulatory T-cell function-IL6, IL6R, IL10, heme-oxygenase 1 (HMOX1), IL2, Toll-like receptor 2 (TLR2), TGFB1, TGF-beta receptor (TGFBR)-1, TGFBR2, IL2RA, and forkhead box protein 3 (FOXP3)-in relation to atopy and asthma.
|
20599261 |
2010 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Wheezy children at a high risk of developing asthma had a significantly lower absolute number of CD4(+)CD25(+) (P=0.01) and CD4(+)CD25(high) (P=0.04), compared with those at a low risk.
|
19438590 |
2009 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings also suggest that treatment with inhaled glucocorticosteroids in asthmatics might increase this FOXP3 protein expression within the CD4(+)CD25(high) T-cell population.
|
19392991 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
An increase in CD25+ T-lymphocyte and CD23 B-lymphocyte populations after food allergen challenge may indicate their significant role in the pathogenesis of the active phase of the immunoinflammatory process in children with asthma and concomitant food allergy.
|
19571570 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The anti-TNF-alpha reagent, etanercept, restored the functional activity and Foxp3 expression of CD4(+)CD25(high) Treg derived from allergic asthmatics.
|
18053016 |
2008 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
RGD |
Thereby, we found a dose-dependent recruitment of cellular markers of allergic asthma including the activated CD4(+)/CD25(+)/CD26(+) T cell subpopulation, which has not been described in asthma yet.
|
17351063 |
2007 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Numbers of CD4(+)CD25(+) and CD4(+)CD25(hi) T lymphocytes were higher in children with persistent allergic rhinitis and/or moderate-severe bronchial asthma than in those with respective milder disease.
|
17349011 |
2007 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The percentages of both CD4 and CD8 T lymphocytes expressing HLA-DR and CD25 were elevated in the asthmatics as compared with controls, and significantly reduced in association with de novo or augmented inhaled glucocorticoid therapy.
|
11826234 |
2002 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Asthmatics had an increasing number of inflammatory cells in BALF, including activated eosinophils (EG2-positive) (p less than 0.001) and activated T cells (CD25-positive) (p less than 0.001).
|
1516385 |
1992 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The six IL-5 mRNA-positive asthmatics tended to have more severe disease than the negative asthmatics, as assessed by symptoms and lung function, and showed a significant increase in the degree of infiltration of the bronchial mucosa by secreting (EG2+) eosinophils and activated (CD25+) T lymphocytes.
|
2022726 |
1991 |