Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Follicular bronchiolitis as phenotype associated with CD25 deficiency.
|
24116927 |
2014 |
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Follicular bronchiolitis as phenotype associated with CD25 deficiency.
|
24116927 |
2014 |
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity.
|
23416241 |
2013 |
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
Biomarker
|
disease |
BEFREE |
PBC is virtually absent in children with the exception of one reported child with interleukin 2 receptor α (CD25) deficiency which is associated with an IPEX-like regulatory T cell dysfunction.
|
20650610 |
2010 |
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
These data show that CD25 deficiency results in an IPEX-like syndrome and suggests that although Foxp3 is not required for normal IL-10 expression by human CD4 lymphocytes, CD25 expression is important.
|
17196245 |
2007 |
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
These data show that CD25 deficiency results in an IPEX-like syndrome and suggests that although Foxp3 is not required for normal IL-10 expression by human CD4 lymphocytes, CD25 expression is important.
|
17196245 |
2007 |
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
GermlineCausalMutation
|
disease |
ORPHANET |
Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor.
|
9096364 |
1997 |
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Interleukin 2 Receptor, Alpha, Deficiency of
|
0.710 |
Biomarker
|
disease |
CTD_human |
|
|
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This finding indicates that the inherited altered genetic constitution at IL2RA may predispose to a less destructive course of RA.
|
31134763 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In contrast, both antibodies induced early and sustained suppression of RA disease markers, including interleukin (IL)-6, C-reactive protein, IL2RA, and matrix metalloproteinase 1, in DMARD-IR patients.
|
30358109 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the minor subsets of CD25+FOXP3low memory Tregs as well as CD25lowCD127lowFOXP3+ Tregs were also increased in children with T1D.
|
30723474 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Insight into the associations of MS-associated <i>IL2RA</i> SNPs, as these new findings provide, offers a better understanding of CD25 variation in the immune system and can lead to new insights into how MS-associated SNPs contribute to development of MS.
|
31242590 |
2019 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphism (rs1800693) of TNFRSF1A (type 1 tumour necrosis factor receptor) encodes a potentially anti-inflammatory soluble truncated form of the p55 receptor, which is associated with predisposition to multiple sclerosis but protection against ankylosing spondylitis (AS).
|
29535371 |
2019 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Daclizumab is a humanized monoclonal IgG1 antibody that binds to CD25 that has been studied for the treatment of multiple sclerosis (MS).
|
30885425 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
RESULTS Compared with the healthy controls, the proportions of CD3+CD4+ T cells and CD3+CD4+CD25+CD127low T cells in the peripheral blood were significantly higher in RA patients.
|
30106887 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The established T1D SNPs rs1159465 (near IL2RA) and rs75352297 (near CCR2 and CCR3) were positively associated with IL-2Rα and CCL4, respectively (P < .01).
|
29266506 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
CTD_human |
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
|
30224649 |
2018 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis aims to evaluate the relationship of the IL2RA polymorphisms rs2104286 and rs12722489 with MS risk in different populations.
|
29648897 |
2018 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We speculate that vitamin D<sub>3</sub> may promote the maintenance of CD25-related immune homeostasis in MS.
|
29153546 |
2018 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Additionally, the FoxP3 MFIs in CD4 + CD25 + T-Cells of IFN-β1a-treated RRMS were significantly lower than the new cases of MS.
|
29589548 |
2018 |