|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No expression of the interleukin-3 (IL-3) gene was identified in any of the 43 primary renal cell tumors.
|
1749019 |
1991 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Messenger RNA encoding for interleukin-1 beta, interleukin-6, and basic fibroblast growth factor was found to be expressed in significant amounts in some of these tumors, while mRNA for interleukin-3 was found in small quantities in only the tumor lines.
|
2191239 |
1990 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This in turn suggests that therapeutic administration of either GM-CSF, IL-3, or IL-6 may involve no additional risk of tumor regrowth in vivo.
|
8319222 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transfectant grew autonomously without IL-3 and SCF, and it formed tumors in nude mice.
|
9797363 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Despite extensive research on cytokine circuitries regulating proliferation and survival of tumor cells in Hodgkin's disease (HD) the functional expression of IL-3Rs in this pathobiological entity has not yet been investigated.
|
11839579 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because interleukin 3-dependent Ba/F3 murine lymphoid cells transfected with the mutant KIT complementary DNA grew autonomously without any growth factors and formed tumors in nude mice, the mutation was considered to be gain-of-function type.
|
11984533 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cell lines are incompletely transformed, as evidenced by their dependence on interleukin 3 (IL-3), and their failure to initiate tumors when injected into immunodeficient mice.
|
17377591 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our proteomic results indicate an elevated concentration of Stem Cell Growth Factor (SCGF), a hematopoietic growth factor having a role in the development of erythroid and myeloid progenitors, in imatinib-responsive tumor areas.
|
21943129 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
More importantly, we demonstrated that miR-125b is able to transform the 32Dclone3 cell line by conferring growth independence from interleukin-3; xenograft experiments showed that these cells form tumors in nude mice.
|
22689670 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, in vivo studies showed that co-expression of the mIL-3 gene significantly increased the HSV-sr39tk/GCV-induced tumor growth delay and even cured the tumor.
|
23441198 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
IL3 rs2073506 G>A polymorphism was associated with an increased risk for ESCC higher tumor, nodal, and metastatic (TNM) stages.
|
23726808 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The fusion proteins GCSF-F8, F8-IL3 and F8-IL4-F8, were cloned, expressed, and their targeting ability assessed, exhibiting preferential tumor uptake with tumor:blood ratios at 24 h after injection of 3.3, 18.2 and 27.3, respectively.
|
29438784 |
2018 |