Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings are of pathophysiological relevance, as assessed by the failure of IL-3-deficient mice to develop airway hyperreactivity, which could be restored by adoptive transfer of IL-3-derived basophils recovered from wild-type mice.
|
29777594 |
2018 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Initially identified as a T cell and mast cell growth factor, interleukin (IL)-9 has long been recognized as an important mediator of asthma.
|
28352305 |
2017 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that IL3 SNP rs40401 is significantly associated with the risk of asthma in young adult Japanese women and reveals that the combination of ever smoking and having the CC genotype of IL3 SNP rs40401 is significantly positively associated with asthma.
|
24684517 |
2014 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The strongest hypothetical biological mechanism was one wherein SNPrs40401 modulates the role of IL3 in several pathways and conditions, including the stem pathway, asthma (hsa05310), the dendritic cell pathway, and development (0.001 < p < 0.004; 0.001 < FDR < 0.033).
|
24293394 |
2014 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TPI ASM8 attenuated a broad range of inflammatory and physiological changes after AIC, suggesting that CCR3, IL-3, and GM-CSF also are important targets for the management of asthma.
|
21605124 |
2011 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-3 can induce basophils to express high levels of amphiregulin, which may contribute to tissue remodeling during type 2 immune responses such as asthma.
|
21036386 |
2010 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the initial sample, three SNPs, rs320995 in the cysteinyl leukotriene receptor 1 gene, rs1047266 in the tumour necrosis factor receptor superfamily, member 10b, gene and rs40401 in the interleukin-3 gene, were associated with risk of asthma.
|
18829683 |
2009 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In two large study populations of children, the German part of the International Study of Asthma and Allergy in Childhood (ISAAC II) and the German Multicentre Atopy Study (MAS), 3099 and 824 children, seven polymorphisms previously associated with the development of atopic diseases were genotyped: two in and around the GM-CSF gene (Ile117Thr and T3085G), one in IL-3 (Pro27Ser), in IL-5 (C-746T), and in the IL-5 high affinity receptor chain IL-5R (G-80A) and two in the common receptor chain CSFR2b for IL-3, IL-5, and GM-CSF (Asp312Asn and Glu249Gln).
|
17362254 |
2007 |
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upregulated CD69 expression on locally accumulated basophils in bronchial asthma may be attributed at least in part to a combination of local cytokines, especially IL-3, plus exposure to low levels of IgE-crosslinking allergens.
|
17541278 |
2007 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic association analysis of polymorphisms revealed that one exonic (exon 1), IL3 + 79T > C ( Ser27Pro), showed significant association with the risk of asthma and atopy.
|
15372320 |
2004 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These observations support the view that atopic and nonatopic asthma are associated with combined bronchial mucosal expression of CC chemokines (RANTES and MCP-3), together with eosinophil-active cytokines (IL-5, GM-CSF, and IL-3).
|
8998072 |
1997 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further assessment made in 15 of the 24 acute asthmatics 7 days after systemic steroid treatment revealed a significant reduction in GM-CSF expression (P < 0.05) but not for IL-3.
|
8835120 |
1996 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glucocorticoid therapy of asthmatics is associated with a reduction in the percentages of CD4 T-LC expressing IL-3, IL-5, and GM-CSF mRNA and secretion of the corresponding proteins.
|
7742019 |
1995 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There were increased proportions of cells positive for IL-3 (p < 0.05), IL-4 (p < 0.005), IL-5 (p < 0.005), and GM-CSF (p < 0.005) mRNA in BAL fluid from patients with symptomatic asthma when compared with that from subjects free of symptoms, but no difference between the groups in numbers of cells expressing IL-2 and interferon-gamma mRNA.
|
8360390 |
1993 |