IL3, interleukin 3, 3562

N. diseases: 211; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 AlteredExpression disease BEFREE CD123, or interleukin 3 receptor alpha, is overexpressed on most AML and some lymphoid malignancies, such as acute lymphocytic leukemia (ALL), and has been an effective target for T cells expressing chimeric antigen receptors (CARs). 27548616 2016
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 GeneticVariation disease BEFREE MLLT10 and IL3 rearrangement together with a complex four-way translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia: A case report. 25435396 2015
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 GeneticVariation disease BEFREE Therefore, bone marrow samples from 100 children with acute lymphoblastic leukemia (ALL) were cultured in the cytokines TNF-alpha, GM-CSF, c-kit ligand, and fetal liver tyrosine kinase 3 ligand, with or without IL-3 and -4 and after administration of HdI valproic acid (VAL), suberoylanilide hydroxamic acid (SAHA), isobutyramid, or trichostatin A. 19129484 2009
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 Biomarker disease BEFREE Receptor-binding for myeloid-associated GF was observed in the majority of precursor B-ALL (G-CSF = 100%, GM-CSF = 65%, IL-3 = 83%, SCF = 74%), but not in T-ALL. 7535143 1994
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 Biomarker disease BEFREE We have previously reported the establishment of an interleukin-3 (IL-3)-dependent and phenotypically myeloid cell line (TALL-103/3), obtained by culturing cells from an immature T-lymphoblastic leukemia in the presence of IL-3. 1379847 1992
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 Biomarker disease BEFREE Thus, HAL-01 is a unique ALL cell line exhibiting proliferative suppression by IL-3 that may prove useful in studying the interactions of cytokines in ALL. 2027299 1991
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 GeneticVariation disease BEFREE Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. 2114933 1990
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 Biomarker disease BEFREE Monitoring of leukemic cell populations in suspension culture by Southern blot analysis of immunoglobulin and T cell receptor gene rearrangements revealed preferential stimulation of the leukemic cell clone by both IL-7 or IL-3 in one cALL and one B-ALL sample. 2388482 1990
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.090 GeneticVariation disease BEFREE The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. 2499362 1989