|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
An IDC uptake assay was performed, and IDCs of healthy and SLE donors were divided into three subgroups following 48 hours of treatment with GM-CSF and IL-4, along with L. delbrueckii, L. rhamnosus, and mixed probiotics for the production of tolerogenic DCs.
|
29943843 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-6, IL-12, IL-17, IFN-γ and IL-10 levels were significantly higher in SLE, while IL-4 was lower in SLE.
|
28649995 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present findings suggest that IL-1β T-31C and IL-4 VNTR polymorphisms but not IL-1β C-511T polymorphism may contribute in SLE pathogenesis.
|
27488002 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, we failed to reveal any association between IL-4 rs2243250 polymorphism and systemic lupus erythematosus (SLE), type 1 diabetes (T1D) or Graves' disease (GD).
|
24628947 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-4 single nucleotide polymorphisms in juvenile systemic lupus erythematosus.
|
25320043 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This Ab (XmAb5871) stimulated phosphorylation of the ITIM of FcγRIIb and suppressed BCR-induced calcium mobilization, proliferation, and costimulatory molecule expression of human B cells from healthy volunteers and systemic lupus erythematosus (SLE) patients, as well as B cell proliferation induced by LPS, IL-4, or BAFF.
|
21357255 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The risk of SLE increased significantly when a subject has two at-risk genotypes for IL4 -590C and STAT6 2892C (odds ratio, 3.24, 95% CI 1.5-7.0, p = 0.003, Bonferroni-corrected p = 0.009), IL4 -33C and STAT6 2892C (odds ratio 3.06, 95% CI 1.4- 6.7, p = 0.005, Bonferroni-corrected p = 0.015), as well as IL4 9241G and STAT6 2892C (odds ratio 3.34, 95% CI 1.6-7.1, p = 0.002, Bonferroni-corrected p = 0.006).
|
20530519 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In patients with SLE with PpXx genotype, IL-10 and IL-4 mRNA expression was higher (P < 0.001 and P = 0.013, respectively), while in patients with SLE with Ppxx genotype IFN-gamma and IL-2 mRNA expression was lower than in controls (P < 0.001).
|
19399944 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
The hypomethylation of the CpG islands of the IL-4 and -6 promoters accrued in T cells from SLE patients and was associated with the severity of SLE at the clinic.
|
18158872 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
CTD_human |
The hypomethylation of the CpG islands of the IL-4 and -6 promoters accrued in T cells from SLE patients and was associated with the severity of SLE at the clinic.
|
18158872 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus.
|
17117487 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We determined the levels of CR1 transcript in the neutrophils from 25 untreated patients with active SLE and 25 normal healthy individuals and, studied the effect of interferon-gamma (IFN-gamma), interleukin-4 (IL-4) and immune complexes (IC) on the same.
|
17049990 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The relative expressions of T-bet/GATA-3 and IFN-gamma/IL-4 correlated with lupus disease activity (r = 0.229, p = 0.042; r = 0.231, p = 0.040, respectively).
|
17117487 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
The rates of genotype polymorphism of TNF-beta +252, IL-4 -590 and IL-10 -819 were significantly correlated with SLE.
|
16193177 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Associations have been reported between single nucleotide polymorphisms (SNPs) of IL-10 and the Ile50Val polymorphism of the IL-4 receptor gene (IL-4R) gene and atopy and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
|
15497451 |
2004 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There was no difference in the levels of IL-4 expression among the SLE groups.
|
12746905 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The genotype frequencies of IL-4 intron 3 were found to differ significantly between SLE patients with and without discoid rash (chi-square test, P = 0.03 5).
|
12587822 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, IL-4 may serve multiple roles in the development of lupus: it may enhance autoantibody production via its direct B-cell effects, protect against autoimmunity via its T-cell suppressor effect, or perpetuate tissue damage via its direct effects on target organs.
|
12921752 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genotype frequencies of IL-4 intron 3 were found to differ significantly between SLE patients with and without discoid rash (chi-square test, P = 0.03 5).
|
12587822 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, the imbalance of IFN-gamma/IL-4 producing CD4+ T cells was due to the decrease in IL-4 producing CD4+ T cells and may play an important pathogenic role in active SLE.
|
12568118 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
By contrast, expression of IL-4 transcripts in PBMC of patients with SLE was significantly decreased compared with the healthy controls (P = 0.0008).
|
11122256 |
2000 |
|
Lupus Erythematosus, Systemic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate herein that the accelerated development of lupus-like autoimmune disease in MRL-lpr/lpr and MRL.Yaa mice, as compared with MRL-lpr/lpr.ll and MRL-+/+ mice, respectively, was correlated with an enhanced expression of IFN-gamma vs IL-4 and IL-10 mRNA in CD4+ T cells, which paralleled with an increase of spontaneous and foreign T cell-dependent antigen-induced productions of IgG2a and IgG3 vs IgG1 antibodies.
|
8601623 |
1996 |