|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We conclude that some AIDS-related lymphomas are associated with eosinophilia and that the eosinophilia may be related to EBV infection and transcriptional activation of the IL-5 gene.
|
1334944 |
1992 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, highly purified blood eosinophils from three out of four patients with eosinophilia were also strongly labeled with the IL-5 antisense but not with the corresponding sense probe.
|
1730922 |
1992 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The induction of detectable levels of IL-5 and GM-CSF in the circulation may explain the eosinophilia and neutrophilia observed in these patients.
|
1912580 |
1991 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest a possible expanded role for the B cell in the induction of eosinophilia, and should serve as a focus for additional investigation into possible roles for IL-5 in human B-cell proliferation and differentiation.
|
2156579 |
1990 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine if interleukin-5 (IL-5) is implicated in producing the eosinophilia, we performed in situ hybridization studies on cytopreparations of 16 cases of Hodgkin's disease with eosinophilia as well as cells from various controls.
|
2403816 |
1990 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
However, nonallergic eosinophilia is independent of IL-4 and IL-5, cytokines that contribute to tissue eosinophilia in allergic inflammation.
|
7560666 |
1995 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, the rapid kinetics of IgE-mediated IL-5 transcription and protein elaboration are consistent with a primary role for mast cell activation directly leading to late-phase airway eosinophilia.
|
7576704 |
1995 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
All cases expressed the IL-3R but the IL-5R gene was expressed predominantly in leukaemic cells with either t(8;21) or CD4-positive immunophenotype and was associated with the presence of eosinophilia.
|
7577627 |
1995 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Transcriptional regulation of the interleukin-5 (IL-5) gene in T lymphocytes appears to be of central importance in the control of the eosinophilia characteristic of allergic responses and certain parasite infections.
|
7718877 |
1995 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
As the causes of persistent eosinophilia in patients with the idiopathic hypereosinophilic syndrome (HES) are (by definition) unknown, a semi-quantitative assay for IL-5 mRNA in eosinophils and mononuclear cells was carried out using samples from 11 patients with HES.
|
7835952 |
1994 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Blood lymphocytes from patients with eosinophilia are known to produce interleukin-5 (IL-5) with appropriate stimulation in vitro.
|
8092143 |
1994 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We describe a patient whose presenting laboratory features of elevated IgG4 and IgE and eosinophilia suggested high levels of IL-4 and IL-5 and in vivo expansion of the CD4+ Th2 subset.
|
8100845 |
1993 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data support a role for GM-CSF and IL-3 in the eosinophilia characteristic of CHS and show that IL-5 mRNA expression is not a prominent feature of nonallergic inflammation.
|
8335853 |
1993 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Our in vitro results suggest that IL-5 produced by activated CD4+ T lymphocytes plays a crucial role in the induction of eosinophilia in HES.
|
8425573 |
1993 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The majority of allografts with evidence of rejection had concomitant IL-5 mRNA and eosinophilia, while no resolving or nonrejecting allografts had simultaneous IL-5 mRNA and eosinophilia.
|
8475567 |
1993 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Role of granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5 in the eosinophilia associated with T cell lymphoma.
|
8485042 |
1993 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This preliminary study suggests that IL-5 mRNA is detectable by polymerase chain reaction in three cases of T-cell lymphoma with eosinophilia.
|
8493995 |
1993 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD(3+)4-(8-) cells might cause eosinophilia.
|
8602991 |
1996 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
This data suggests that the development of tissue eosinophilia in vivo involves a two-step mechanism elicited by interleukin 5 and eotaxin.
|
8784786 |
1996 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
Oral administration of CDP840 caused a dose-dependent reduction of interleukin-5 (IL-5)-induced pleural eosinophilia in rats (ED50 = 0.03 mg kg-1).
|
8818342 |
1996 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
The IL-5 gene was expressed in the tumor tissues, suggesting that the eosinophilic invasion and eosinophilia were caused by IL-5 derived from the lymphoma cells.
|
8922493 |
1996 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
The presence of eosinophilia in most HD patients and the presence of hyper-IgE in a subset of them may suggest that activated lymph node T cells release large amounts of IL5 and IL4, respectively.
|
9407718 |
1998 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of matrix metalloproteinase-1 mRNA related to eosinophilia and interleukin-5 gene expression in head and neck tumour tissue.
|
9463570 |
1997 |
|
Eosinophilic disorder
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, development of eosinophilia depends on overexpression of IL-4 and IL-5, because it is strongly inhibited by administration of neutralizing antibodies to either of these cytokines.
|
9516119 |
1998 |
|
Eosinophilic disorder
|
0.100 |
Biomarker
|
group |
BEFREE |
In asthma, airway eosinophilia is believed to be mediated by cytokines such as interleukin-5 and granulocyte-macrophage colony stimulating factor (GM-CSF).
|
9525446 |
1998 |