|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Subgroup analysis indicated elevated serum IL-6 in both the depression and manic phases in BD patients.
|
30762747 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study is clinically relevant because we highlight that, in agreement with the previous literature, IL-6 appears to be a useful marker in depression, and we show for the first time that its reduction is closely related to the use of ECT.
|
28521271 |
2017 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the depression-associated module was highly enriched for pathways related to immune function and was also associated with TL and IL-6 cytokine levels.
|
29790996 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups.
|
31823093 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.
|
30854996 |
2020 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
It was observed that Interleukin-6, salivary cortisol, arachidonic acid / eicosapentaenoicacid plus docosahexaenoic acid ratio, and genetic polymorphisms may present variations which are linked to a predisposition to INF-α-induced depression.
|
27936453 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In a model additionally adjusted for depression, vascular factors, BMI, and smoking status, the association between IL6 and brain volumes remained, and a doubling in ACT was marginally associated with 0.054 (p=0.001) millimeter thinner mean cortical thickness, equivalent to that of approximately 2.7years of aging.
|
28457809 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the underlying mechanism of this relationship is still not fully explained, while interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with depression and exercise.
|
28096677 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggest that IL-6 may exert neuroprotection within CA1 neurons via pleiotropic mechanisms and may serve as a potential therapeutic target for the treatment of depression.
|
31394209 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The depressed rats showed a significant rise in serum cortisol, NO, IL-6 and IL-1β (p<0.001).TMS antagonized depression and anxiety.
|
28189098 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leukocyte telomere length was compared between 18 unmedicated MDD subjects and 17 controls and was correlated with lifetime depression chronicity and peripheral markers of oxidation (F2-isoprostane/Vitamin C ratio) and inflammation (IL-6).
|
21448457 |
2011 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We assessed trauma exposure, PTSD and depression severity, and quantified a panel of pro- inflammatory cytokines, including interleukin (IL)-1β, IL-2, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), interferon ϒ (IFN<sub>ϒ</sub>), and anti-inflammatory cytokines, including IL-4, IL-10 and IL-13 with enzyme-linked immunosorbent assays.
|
30711869 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A significant correlation was observed between the patients' plasma IL-6 levels and their 17-item Hamilton Rating Scale for Depression (HAMD17) scores (<i>r</i> =0.4555, <i>P</i>=0.0010).
|
28243095 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Accumulating evidence suggests that pro-inflammatory cytokines such as interleukin-6 (IL-6) have an important role in the pathogenesis of depression.
|
28556833 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Among people with only an alcohol use disorder, IL-6 was positively associated with depression and psychological distress scores, and IL-10 was negatively associated with anxiety score.
|
29500107 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-6 supports tumour growth and metastasising in terminal patients, and it significantly engages in cancer cachexia (including anorexia) and depression associated with malignancy.
|
30178819 |
2019 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Improvement in depression was correlated with increased IL-6 sR (r = -0.59 p = 0.02).
|
30962090 |
2020 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Depression was directly related to evening salivary cortisol and inflammation, such that higher evening cortisol predicted greater depressive symptoms (β=0.215, p<0.01) and higher pro-inflammatory cytokines (interleukin-2 [IL-2], IL-6, and tumor necrosis factor-alpha [TNF-α] levels (β=0.185, p<0.05), when controlling for covariates.
|
28918107 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Further bivariate modeling revealed that approximately 10% of the correlation between Beck Depression Inventory and IL-6 could be explained by the SLC6A4 gene.
|
20031642 |
2009 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Elderly with depression have higher IL-6 than controls, while those with Alzheimer's disease did not have higher peripheral inflammatory markers.
|
30104698 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The main objectives of this study are to test whether IL-6 contributes to the pathogenesis of depression and to examine potential mechanisms by which IL-6 affects mood and cognition.
|
30244217 |
2018 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studies found that elevated levels of cytokines such as interleukin- (IL-) 1<i>β</i>, IL-6, and tumor necrosis factor-<i>α</i> (TNF-<i>α</i>) are closely associated with the pathogenesis of depression.
|
29765402 |
2018 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Having in mind the hypothesis of impaired cytokine regulation in depressive disorder, as well as the diverse population-dependent results for cytokine polymorphisms, we investigated the relation between the cytokine gene polymorphisms of key pro- and anti-inflammatory cytokines (TNF-α, TGF-β, IL-10, IL-6, IFN-γ) and susceptibility as well as clinical course of depression in Bulgarians.
|
27049572 |
2016 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, AD patients with depression have even significantly higher levels of IL 6 or TNF α and a lower level of 25-hydroxyvitamin D in circulation than in AD patients without depression.
|
28580183 |
2017 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
During late phase, LPS-induced increases in cortisol and IL-6 plasma concentrations and baseline depression were significant predictor variables, explaining 38.5% of variance.
|
28074475 |
2017 |