|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-6, TNF-α, and inflammatory related molecules ICAM-1, VCAM-1, MMP-2 and -9, nuclear NF-kB, and iNOS, were elevated in MI-V.
|
30642049 |
2019 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both adrenergic stimulation and high levels of interleukin-6 (IL-6) indicate an unfavorable outcome in patients with myocardial infarction or heart failure.
|
31749886 |
2019 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study examined whether molecular variations at the IL-6 locus are involved in the predisposition to myocardial infarction.
|
11485024 |
2001 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic and environmental influences on the plasma interleukin-6 concentration in patients with a recent myocardial infarction: a case-control study.
|
21087078 |
2011 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Another 20 mice with IL-6 gene knockout were enrolled into the MI + IL-6 KO group.
|
31364133 |
2019 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Large genetic human studies, using Mendelian randomization approaches, have clearly showed that IL-6 pathway is causally involved in the onset of myocardial infarction.
|
28250574 |
2017 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In subgroup analyses stratified by ethnicity, study scale, thrombotic category, and country, the results indicated that IL-6 gene-174 G/C polymorphism was significantly associated with increased risk of thrombotic disorders given the conditional such as Asians, large sample-sized, MI, population-based, and Indian studies (C carriers vs GG: 1.39 [1.13-1.72] and C allele vs G allele: 1.36 [1.18-1.56] for Asian; C carriers vs GG: 1.15 [1.01-1.31] and C allele vs G allele: 1.12 [1.01-1.23] for large sample-sized studies; C allele vs G allele: 1.10 [1.03-1.18] for population-based studies; and C carriers vs GG: 1.40 [1.19-1.65] for Indian studies).
|
27399086 |
2016 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transcript levels of the pro-inflammatory cytokines interleukin-6 and interleukin-1β were upregulated in hearts of vehicle treated animals compared to mice without MI.
|
29169754 |
2018 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 -174 promoter polymorphism.
|
16313298 |
2005 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In healthy men, fibrinogen haplotypes are associated with serum IL-6 concentrations in a manner consistent with their impact on MI risk.
|
17241179 |
2007 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the effect of G894T polymorphism on endothelial function, on markers of endothelial cells injury and activation such as von Willebrand factor (vWF) and on serum levels of proinflammatory cytokines such as interleukins 6 (IL-6) and 1b (IL-1b), in young myocardial infarction (MI) survivors.
|
16337503 |
2006 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Individual alleles and haplotypes were studied for association with levels of the inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and C-reactive protein and risk for MI.
|
17002900 |
2006 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the presence of high IL6 serum levels, the -1738A allele increased and the 2860A allele reduced the risk of MI (all p < or = 0.02).
|
19404549 |
2009 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we also did not find significant association between IL-6 gene -174 G/C polymorphism and myocardial infarction (MI) risk.
|
22575724 |
2012 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-6 (IL-6) has been found to be a predictor of heart attack.
|
28233119 |
2017 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequently they were tested for IL-6 secretion inhibition in RAW 264.7 macrophages and for cardiac function protection against adverse remodeling after MI in C57BL/6J mice.
|
28065862 |
2017 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is known that increased plasma levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with atherosclerosis and myocardial infarction.
|
15969253 |
2005 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated variation in inflammation-related genes - interleukin (IL)-1beta, IL-6, C-reactive protein (CRP), IL-10, IL-18, and the tumor necrosis factor (TNF) superfamily [lymphotoxin(LT)-alpha, TNF-alpha, LT-beta] - with respect to nonfatal incident myocardial infarction (MI) or ischemic stroke risk.
|
17981284 |
2008 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Impaired downregulation of gp130-mediated STAT3 activation in subacute infarction promotes cardiac inflammation, adverse remodeling, and heart failure, suggesting a potential causative role of high interleukin-6 serum levels after myocardial infarction.
|
20585009 |
2010 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we investigated products of complement activation, C3d and soluble C5b9 (sC5b9), as potential biomarkers for myocardial injury and inflammation, as well as serum cytokines (IL-6 and TNF-alpha), alpha-1-acid glycoprotein (AGP), and classical markers of myocardial necrosis (creatine kinase, creatine kinase-MB isoform, myoglobin and troponin-I) in a longitudinal study of patients with AMI (from admission, 6 h and 12 h post admission, and at discharge from hospital).
|
29908956 |
2018 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated joint associations of fibrinogen and IL6 tagSNPs with fibrinogen concentrations, carotid intima-media thickness, and myocardial infarction or ischemic stroke in 3900 European-American Cardiovascular Health Study participants.
|
20059469 |
2010 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up.
|
30934019 |
2019 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men.
|
20585578 |
2010 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C) with levels of inflammatory markers and risk of myocardial infarction (MI) in a European study of MI survivors and age-matched controls from two high-risk centres in the North of Europe, and two low risk centres in the South.
|
15543342 |
2004 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
We repeatedly determined plasma IL-6 in 955 myocardial infarction survivors from six European cities (n = 5,539).
|
19750100 |
2009 |