|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We present new findings that Lyp promotes TLR responses in primary human monocytes and that the autoimmunity risk Lyp620W variant is more effective at promoting TLR-induced interleukin-6 than the non-risk Lyp620R protein.
|
26683155 |
2016 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis.
|
26640809 |
2015 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
However, more recent evidence from various autoimmune diseases (e.g., inflammatory bowel disease, rheumatoid arthritis) has shown that the IL-6 activity is more complex with important effects also on tissue homeostasis, regeneration, and metabolism.
|
28642760 |
2017 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These results suggest that -174 IL-6 (rs1800795) gene polymorphism plays a role in the response to rituximab in systemic autoimmune diseases.
|
22734797 |
2012 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Aire can also be expressed in dendritic cells (DCs), and DCs can mediate T follicular helper (T<sub>FH</sub>) cell differentiation and self-reactive B cell activation through inducible costimulator molecule ligand (ICOSL) and interleukin 6 (IL-6), which can cause autoimmune diseases.
|
31023489 |
2019 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
AT-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) required for autoimmunity via stabilization of interleukin-6 (Il6) and signal transducer and activator of transcription 3 (STAT3) mRNAs.
|
29244194 |
2018 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The role of IL-6 in regulating progressive CNS autoimmunity was assessed by treating GFAPγR1Δ mice with anti-IL-6 neutralizing antibody during chronic EAE.
|
25896970 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Kawasaki disease was associated with higher IL-17A and IL-6, a cytokine profile similar to other autoimmune diseases.
|
25585854 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Specific phase of this chronic and deteriorating disorder must be considered, which can involve IL-6 in acute or possible chronic inflammation and/or autoimmunity.
|
29163240 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Here we review the evidence for the involvement of IL-6 in the pathophysiology of autoimmune diseases and chronic inflammatory proliferative diseases (CIPD) and discuss the possible molecular mechanisms of its involvement.
|
12220549 |
2003 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Systemic lupus erythematosus (SLE) is the prototype of human autoimmune disease in which various inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, IL-6 and interferon (IFN) play crucial pathogenic roles.
|
23139385 |
2013 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
A study in mice demonstrated that IL-6 promotes the development of a new type of T-helper cells called Th17 cells that impact the pathogenesis of autoimmune diseases.
|
17978466 |
2007 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-6 has an important role in the pathogenesis of autoimmunity and chronic inflammation.
|
30178083 |
2018 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Specifically, the cellular processes related to cell proliferation (for example, epidermal growth factor, platelet-derived growth factor, nuclear factor-κB, Wnt/β-catenin signaling, stress-activated protein kinase c-Jun NH2-terminal kinase), inflammatory response (for example, interleukins IL2 and IL6, the cytokine granulocyte-macrophage colony-stimulating factor and the B-cell receptor), general signaling cascades (for example, mitogen-activated protein kinase, extracellular signal-regulated kinase, p38 and TRK) and apoptosis are activated in most of the analyzed autoimmune diseases.
|
23190644 |
2013 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
LHGDN |
Here we review the evidence for the involvement of IL-6 in the pathophysiology of autoimmune diseases and chronic inflammatory proliferative diseases (CIPD) and discuss the possible molecular mechanisms of its involvement.
|
12220549 |
2003 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
While experimental models of myocarditis have clearly linked IL-6 to the generation of pathogenic autoreactive T cells, IL-6 has exhibited a protective role in autoimmune disease development in viral-induced disease models.
|
19758168 |
2009 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Therefore, the attenuated autoimmunity following loss of IL-4 and IL-6 is dose-dependent, as higher doses of Hg are able to override the attenuation observed using lower doses.
|
19077085 |
2009 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Like other autoimmune diseases, Th17 cells and their effector cytokines (such as interleukin 6) have been implicated in pathogenesis.
|
23202933 |
2012 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
<b>Objectives:</b> Oncostatin M (OSM), a pleiotropic cytokine and a member of the gp130/IL-6 cytokine family, has been implicated in the pathogenesis of autoimmune diseases.
|
31555281 |
2019 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Levels of hydrogen peroxide (H(2)O(2)) and interleukin-6 (IL-6), a proinflammation cytokine and a key factor in the pathogenesis of autoimmune diseases, have been reported to be elevated in vitiligo lesions.
|
22871993 |
2012 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Blockade of IL-6 family cytokines has been shown to be beneficial in autoimmune diseases, but bacterial infections and metabolic side effects have been observed.
|
28620096 |
2018 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Neutralization of IL-6 represents an attractive therapeutic option in several diseases, including B cell neoplasia, osteoporosis, and autoimmunity.
|
11254686 |
2001 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Pharmacokinetics and C-reactive protein modelling of anti-interleukin-6 antibody (PF-04236921) in healthy volunteers and patients with autoimmune disease.
|
29776017 |
2018 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The AT-rich interactive domain-containing protein 5a (Arid5a) plays a critical role in autoimmunity by regulating the half-life of Interleukin-6 (IL-6) mRNA.
|
28168301 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
However, few data on classic and trans-signaling IL-6 in autoimmune thyroid diseases and HIV<sup>+</sup> subjects developing autoimmune disorders are currently available.
|
29055566 |
2018 |