|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The presence of IL-6 and IL-8 in the arterial wall where complement activation also occurred, clearly show the involvement of inflammatory events in initiation and progression of atherosclerosis.
|
9125317 |
1996 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Similarly the individual's IL-6 genotype may be highly relevant in other conditions where IL-6 has been implicated, such as atherosclerosis.
|
9769329 |
1998 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-11 (IL-11), a member of IL-6-like cytokines, is reported to be involved in inflammation and tissue remodeling, both of which are observed in atherosclerosis.
|
10407498 |
1999 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously reported that peroxisome proliferator-activated receptor alpha (PPARalpha) ligands (fibrates) lower elevated plasma concentrations of IL-6 in patients with atherosclerosis and inhibit IL-1-stimulated IL-6 secretion by human aortic smooth muscle cells (SMC).
|
10542237 |
1999 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis.
|
11116068 |
2000 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, a common polymorphism of the IL-6 gene promoter, influencing the transcription rate of the gene, has been described and associated with atherosclerosis of carotid and coronary arteries.
|
12217290 |
2002 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
IL-6 was associated with increased atherosclerosis when the control group was compared with the group free of subclinical CVD.
|
12482836 |
2002 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-6 was associated with increased atherosclerosis when the control group was compared with the group free of subclinical CVD.
|
12482836 |
2002 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS).
|
12574550 |
2003 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This could be of importance for the association between cytokines (e.g., IL-6) and insulin resistance and atherosclerosis.
|
12736161 |
2003 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study demonstrated that in a large healthy family population, children included, levels of IL-6 are closely associated with traditional and non-traditional atherosclerosis risk factors.
|
14612208 |
2003 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
As IL-6 increases in atherosclerosis, the study of the polymorphism of IL-6 may be a useful tool in identifying old subjects at risk for atherosclerosis.
|
15050298 |
2004 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokines including interleukin-6 (IL-6) are supposed to play a pivotal role in the development of atherosclerosis.
|
15604420 |
2005 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
To elucidate the respective roles of DNA polymorphisms in genes that encode inflammatory markers (such as IL-10, IL-6 and TNF-alpha) and other factors that may affect the development of atherosclerosis (such as apolipoprotein E, transforming growth factor and fetuin-A), sufficiently powered studies are needed in which genotype, the protein product and the specific phenotype all are analysed in relation to outcome.
|
15953127 |
2005 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Thus, these two SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese.
|
15969253 |
2005 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, these two SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese.
|
15969253 |
2005 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is unknown whether IL-6, a central regulator of inflammation, is a cause of or just a marker of atherosclerosis.
|
16467451 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha), are suggested to have an important role in the process of atherosclerosis.
|
16487030 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this paper, we reviewed data regarding to the pivotal role played by the zinc-gene interaction in affecting some relevant cytokines (IL-6 and TNF-alpha) and heat shock proteins (Hsp70-2) in ageing, successful ageing (nonagenarians) and in some age-related diseases (atherosclerosis and infections).
|
16513158 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic inflammation due to high IL-6 production occurs in type 2 diabetes (NIDDM) and atherosclerosis.
|
16518702 |
2005 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?
|
16620830 |
2007 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Counteracting pro- and anti-inflammatory responses of serum cytokines have been reported, but the relevance of TNF-alpha, TGF-beta and IL-6 gene expression in peripheral blood leukocytes and their contribution to systemic inflammation in atherosclerosis, especially after acute myocardial infarction (AMI), has not been investigated yet.
|
16718633 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data underline the central role of IL-6 in low-grade inflammation contributing to atherosclerosis and CVD.
|
16900203 |
2006 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To better clarify the role of CD14 in atherosclerosis, we typed CD14 C-260T polymorphism in old Italian (Central of Italy) atherosclerotic patients with carotid stenosis related to lipid assessment, inflammation (soluble CD14, IL-6 serum levels) and IL-6, TNF-alpha, IL-10, Metallothioneins (MT) gene expressions in carotid plaques.
|
17098305 |
2007 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis.
|
17255532 |
2007 |