|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To investigate increased gut permeability (a "leaky gut") as one potential mechanistic pathway from marital distress and depression to heightened inflammation, this secondary analysis of a double-blind, randomized crossover study examined serial assessments of two endotoxin biomarkers, LPS-binding protein (LBP) and soluble CD14 (sCD14), as well as C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) during two separate 9.5 h visits.
|
30098513 |
2018 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The present study suggests that changes in the GSH-dependent defense system, NF-κB activation and increased IL-6 protein expression may have a role in social isolation-induced changes in a rat model of depression and anxiety, and contributes to our understanding of the mechanisms that underlie the antidepressant and anti-inflammatory activity of Flx in socially isolated rats.
|
28474231 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Further bivariate modeling revealed that approximately 10% of the correlation between Beck Depression Inventory and IL-6 could be explained by the SLC6A4 gene.
|
20031642 |
2009 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
IL-6 in childhood were associated with subsequent risk of depression or psychotic disorders in early adulthood and in a dose dependent manner.
|
30439824 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hierarchical regression analyses (controlling for sex, age and the shared variance of risk and resilience factors) showed that (i) cognitive depression was significantly predicted by negative self-judgement and reduced cognitive empathy; (ii) abundance of Lactobacillus spp. was directly related to positive self-judgement but only indirectly to cognitive depression and lower affective empathy (both through self-judgement); and (iii) CRP was the strongest predictor of reduced cognitive empathy, with suppression effects seen for age (negative) and IL-6 (positive) after controlling for CRP.
|
30955108 |
2019 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Interestingly, the depression-associated module was highly enriched for pathways related to immune function and was also associated with TL and IL-6 cytokine levels.
|
29790996 |
2018 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Here, in a sample of 88 healthy female participants, we first assessed the effect of an acute laboratory stress paradigm on levels of plasma interleukin-6 (IL-6), a cytokine known to be both responsive to stress and elevated in depression.
|
28506437 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Improvement in depression scores was associated with improvement in 3 biomarkers of insulin resistance (homeostatic model assessment [HOMA-IR], oral glucose tolerance test, and fasting plasma glucose) and 1 biomarker of inflammation (interleukin-6) among 21 biomarkers studied.
|
27978584 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study is clinically relevant because we highlight that, in agreement with the previous literature, IL-6 appears to be a useful marker in depression, and we show for the first time that its reduction is closely related to the use of ECT.
|
28521271 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The association between the IL-6 polymorphism and reduced risk of depressive symptoms confirms the role of the inflammatory response system in the pathophysiology of IFN-alpha-induced depression; in contrast, the effect of the 5-HTT gene was small and perhaps dependent on the status of the inflammatory response.
|
18458677 |
2009 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, levels of serum CRP, IL-6, TNF-α and BDNF can be used as judgment indicators for the severity of depression.
|
29849779 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups.
|
31823093 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Subgroup analysis indicated elevated serum IL-6 in both the depression and manic phases in BD patients.
|
30762747 |
2019 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The mechanism of its antitumor effect involved in (a) reducing oxidative stress injury through up-regulating activities of CAT and SOD; (b) down-regulating the levels of inflammatory factors, like TNF-α, IL6, COX-2, and PGE2; (c) activation of caspase-3 and up-regulating the pro-apoptotic protein Bax; (d) decreasing the expression of PCNA; (e) depressing the expression of cancer stem cells marker CD133; (f) suppressing aberrant expression of cytokeratin 8 and 18; and (g) inhibiting EGFR/ PI3 K/Akt, EGFR/Ras/Erk and NF-κB pathways.
|
27991692 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Leukocyte telomere length was compared between 18 unmedicated MDD subjects and 17 controls and was correlated with lifetime depression chronicity and peripheral markers of oxidation (F2-isoprostane/Vitamin C ratio) and inflammation (IL-6).
|
21448457 |
2011 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, mGluR5 deficiency dramatically inhibits cytokines release from bone marrow cells, such as IL-1β, TNF-α and IL-6, alleviating proinflammatory responses in LPS-induced depression model.
|
30682501 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Improvement in depression was correlated with increased IL-6 sR (r = -0.59 p = 0.02).
|
30962090 |
2020 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, the underlying mechanism of this relationship is still not fully explained, while interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with depression and exercise.
|
28096677 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Then histone acetyltransferase (HAT), histone deacetylase (HDAC), H3K27ac, NET, TNF-α, and interleukin-6 (IL-6) were detected by western blot in nine female subjects in different depression and hypertension groups, and Chromatin immunoprecipitation-polymerase chain reaction (Chip-PCR) were used to confirm the degree of acetylation affecting on the transcription level of NET gene.
|
30957546 |
2020 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Here we present evidence suggestive of interaction with childhood maltreatment for novel loci in IL-6 (rs1818879) and CRP (rs3093077), increasing risk of depression.
|
28867280 |
2018 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Secondary outcomes encompass self-rated depression (Beck Depression Inventory), attention towards the partners face during PSI (eye tracking), stress-related biomarkers (cortisol, α-amylase, interleukin (IL)-1ß/IL-6, heart rate variability), methylation of oxytocin-receptor-genes and serotonin-transporter-genes and self-ratings of psychological constructs such as relationship quality and empathy.
|
30287601 |
2018 |
|
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores.
|
31686824 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
It was observed that Interleukin-6, salivary cortisol, arachidonic acid / eicosapentaenoicacid plus docosahexaenoic acid ratio, and genetic polymorphisms may present variations which are linked to a predisposition to INF-α-induced depression.
|
27936453 |
2017 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Individuals with depression (current MDD or high depressive symptoms) had lower IL6 methylation levels at one of the four sites investigated, however the effect size was small (∆ 2.4%, SE 0.009, p = 0.006).
|
29070016 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Explorative analyses revealed significant associations between the IL-6 response on the second exposure with perceived stress (r=0.58; p=0.004), vital exhaustion (r=0.57; p=0.009), depression (r=0.47; p=0.026) and purpose in life (r=-0.50; p=0.04).
|
27916659 |
2017 |