|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.
|
31718563 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> An IL-6 point-of-care assay was developed as potential tool for rapid clinical decision making and management of patients with sepsis and/or cytokine release syndrome.
|
31547696 |
2019 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Plasma levels of miR-187 in sepsis patients were inversely correlated with those of TNF-α and IL-6 (r = -0.2841, -0.2163), and plasma levels of miR-21 and miR-145 were positively correlated with those of TNF-α and IL-6 (r = 0.615, 0.3057, 0.4465, 0.2734).
|
31415369 |
2019 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
SDC-1, Ang-2, sTM, VAP-1 and IL-6 levels were measured at ICU admission from 619 patients with sepsis.
|
31512003 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our study highlights the Janus-faced role of IL-6 family cytokines during inflammation, which may explain the failure of IL-6-targeted anti-inflammatory approaches in the treatment of sepsis.-Sackett, S. D., Otto, T., Mohs, A., Sander, L. E., Strauch, S., Streetz, K. L., Kroy, D. C., Trautwein, C. Myeloid cells require gp130 signaling for protective anti-inflammatory functions during sepsis.
|
30726111 |
2019 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Mice subjected to mild IH did not differ from normoxic controls, except a higher IL-6 level after sepsis induced.
|
31501504 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Sepsis increased plasma interleukin-6 (IL-6) and IL-10 and clonidine further increased IL-10 (1.6 ± 0.1 to 3.3 ± 0.7 ng/mL), but not IL-6.Clonidine reduced rectal temperature.
|
29489737 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Diagnostic accuracy of interleukin-6 for early-onset sepsis in preterm neonates.
|
30966828 |
2019 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In the sepsis cohort CSF NT-proCNP levels correlated with CSF Interleukin-6 (IL-6) levels (r = 0.616, p < 0.05) and systemic inflammation represented by high plasma procalcitonin (PCT) levels at day 3 (r = 0.727, p < 0.05).
|
30423400 |
2019 |
|
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Comparing fine filter vs control filter cohort, respiratory dysfunction (Horowitz index 206 (119-290) vs 191 (104.75-280); P = 0.04), pneumonia (11.4% vs 14.4%; P = 0.02), sepsis (9.6% vs 12.2%; P = 0.03), interleukin-6 (471.5 (258.8-1062.8) ng/l vs 540.5 (284.5-1147.5) ng/l; P = 0.01), and length of ICU (1.2 (0.6-4.9) vs 1.7 (0.8-6.9) days; P < 0.01) and hospital stay (14.0 (9.2-22.2) vs 14.8 (10.0-26.8) days; P = 0.01) were reduced.
|
31757216 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We aimed to systematically assess the overall value of interleukin 6 (IL-6) in diagnosing neonates with sepsis.
|
30734480 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The α7 nAChR partial agonist GTS-21 reduces secretion of pro-inflammatory cytokines including interleukin-6 (IL6) and tumor-necrosis factor (TNF) in models of endotoxemia and sepsis, and its anti-inflammatory effects are widely ascribed to α7 nAChR activation.
|
30947238 |
2019 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The absence of TRPM2 triggered less production of inflammatory mediators (IL-1β, IL-6, TNF-α) and decreased apoptosis related proteins (BNIP3, AIF, Endo G) expressions in response to LPS induced sepsis.
|
31450153 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-11 (IL-11) is an interleukin-6 (IL-6) family cytokine shown to play a protective role in acute inflammatory settings including systemic infection.
|
31415618 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Administration of fasudil led to reductions in polymorphonuclear neutrophil counts, and the protein concentrations of tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6 in the bronchoalveolar lavage fluid of rats with sepsis‑induced ALI.
|
30221694 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL6 had the most sensitivity and IL10 had the most specificity for diagnosis of sepsis.
|
29239828 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therefore, DILC may mediate the crosstalk between the cascades of IL‑6/STAT3 and TNF‑α signaling, indicating that DILC may act as a prognostic biomarker of sepsis, and may serve as a potential therapeutic target for the treatment of sepsis.
|
30365067 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Alterations in plasma levels of DcR3, PCT, CRP, and IL-6 were measured by ELISA and compared among patients with sepsis (<i>n</i> = 134), SIRS (<i>n</i> = 60) and normal adults (<i>n</i> = 50).
|
29541387 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Serum markers associated with the acute proinflammatory phase of sepsis (TNFα, IL-1β, and IL-6) rapidly increased and then progressively decreased during the 30-day period post-CLP, concomitant with a progressive increase in RAGE ligands (S100B, <i>N</i>ϵ-[carboxymethyl]lysine, HSP70, and HMGB1).
|
29127203 |
2018 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Stimulation with S. epidermidis sepsis strains induced higher IL-6 and IL-10 expression than stimulation with colonization strains.
|
30146415 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
During invasive infections, an excessive release of pro-inflammatory cytokine, such as interleukin-6 (IL-6), thus IL-6 gene is significant, as a diagnostic marker of systemic infection of the newborns.
|
30505181 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
After excluding the compounds which are previously known to intervene sepsis or which show cytotoxicity to macrophages, the compounds which show dose-dependency in inhibiting the release of IL-6 and TNF-α by the OMV-stimulated macrophages in vitro and which reduce OMV-induced SIRS in vivo are selected.
|
29683274 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Multivariate logistic regression analysis showed that early MCP-1, ISS, and IL-6 were independent risk factors for sepsis in severe trauma patients.
|
29620667 |
2018 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, PAG treatment significantly increased the expression levels of nuclear factor-κB and interleukin-6, and decreased transforming growth factor-β1 expression when compared with the sepsis group.
|
30214506 |
2018 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Patients with sepsis following multiple trauma exhibited significantly higher IL-6 mRNA and protein levels than patients without sepsis (P<0.05).
|
30233734 |
2018 |