|
Osteopenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between bone loss and promoter polymorphism in the IL-6 gene in elderly Japanese women with hip fracture.
|
12811627 |
2003 |
|
Osteopenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In postmenopausal women the mean rate of loss at the ultradistal radius was significantly associated with IL-6 genotypes (ANOVA, p = 0.049), with women having the CC genotype showing a significantly greater rate of bone loss (p < 0.05) compared with their GC and GG counterparts.
|
12110411 |
2002 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased levels of the multifunctional cytokine IL-6 in inflammatory diseases have been proposed to be the link in such "inflammation-mediated osteopenia."
|
11713964 |
2001 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have investigated the expression and synthesis of potential bone-resorbing cytokines, interleukin-6 (IL-6), interleukin-1 (IL-1), and tumor necrosis factor (TNF) in rheumatoid arthritic (RA) and osteoarthritic (OA) bone, two common diseases which are associated with bone loss.
|
11329621 |
2001 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-6 and PGE2 released from osteoblast-lineage cells could be, at least in part, responsible for human inflammation-induced bone loss.
|
11281165 |
2001 |
|
Osteopenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that ETOH may contribute to bone loss through activation of signal transduction that results in production of an osteoclastogenic cytokine (i.e., interleukin-6) in osteoblasts.
|
11182374 |
2001 |
|
Osteopenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density.
|
11355017 |
2001 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-6 is a potent mediator of inflammatory processes, and it has been proposed that the age-associated increase in IL-6 accounts for certain of the phenotypic changes of advanced age, particularly those that resemble chronic inflammatory disease [decreased lean body mass, osteopenia, low-grade anemia, decreased serum albumin and cholesterol, and increased inflammatory proteins such as C-reactive protein (CRP) and serum amyloid A].
|
10774463 |
2000 |
|
Osteopenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Noncarriage of the 240-base pair allele of the IL-1ra gene and carriage of the 130-base pair allele of IL-6 were independently associated with increased bone loss.
|
11040178 |
2000 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We measured cytokine mRNA (IL-1beta, IL-1ra, IL-6, and TNF-alpha) directly in bone biopsies from early postmenopausal women to determine if a lower compensatory increase in IL-1ra mRNA could be demonstrated in women with rapid bone loss after the menopause.
|
10678408 |
2000 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
One candidate gene, interleukin 6 (IL-6), has been implicated in the pathogenesis of bone loss because it stimulates osteoclasts.
|
10319577 |
1999 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
As both basal and PTH-stimulated production of IL-6 and IL-11 are decreased by dexamethasone, the increased bone resorption observed in glucocorticoid-induced osteopenia does not appear to be mediated by IL-6 or IL-11.
|
10467228 |
1999 |
|
Osteopenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results provided strong evidence that genetic variation at the interleukin-6 locus affects regulation of bone mineral metabolism and confers risk for osteopenia and osteoporosis in adult women.
|
10987653 |
1999 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that IL-13 may cause bone loss due to impaired osteoblastic growth and IL-6-induced osteoclast recruitment.
|
9745442 |
1998 |
|
Osteopenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This evidence demonstrates that male sex steroids, acting through the androgen-specific receptor, inhibit the expression of the IL-6 gene; and that IL-6 mediates the upregulation of osteoclastogenesis and therefore the bone loss caused by androgen deficiency, as it does in estrogen deficiency.
|
7769130 |
1995 |
|
Osteopenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even though these observations establish that IL-6 is an essential pathogenetic factor in the bone loss caused by gonadal deficiency, it remains unclear whether IL-6 is the sole pathogenetic factor or whether IL-1, TNF, and IL-11 may also be involved.
|
8579900 |
1995 |