|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chronic HFD-induced obesity is associated with hepatic IL-6 resistance due to saturated FA-induced ER stress.
|
31085628 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that obesity promotes CNS inflammation in EAE through IL-6 and CCL-2 mediated the inflammatory cells infiltration.
|
31507583 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The presence of obesity at ≥ 2 follow-ups showed the highest mean values (SE) for IL-6 [2.45 (1.05)] and CRP [3.74 (1.11)] and the lowest mean value for adiponectin [8.60 (0.37)] (adjusted analyses, females) compared with other exposures; the highest mean of IL-6 [1.65 (1.05)] and CRP [1.78 (1.11)] and the lowest mean of adiponectin [9.98 (0.38)] were for the number of follow-ups with ≥2 exposures compared to those with no exposures at any follow-up (adjusted analyses, females).
|
31071114 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Additionally, mediation effects of high-sensitive C-reactive protein and interleukin-6 (IL6) measured in blood were related to obesity and WMH using linear regression and structural equation models.
|
30556596 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-α expression in the WAT.
|
27083404 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to a diet-induced obesity model, we also examined the role of adipocyte-derived IL-6 in a genetic model of obesity and insulin resistance by crossing the AdipoIL-6<sup>-/-</sup> mice with leptin-deficient (<i>ob/ob</i>) mice.
|
31386565 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Higher rates of esophageal cancer cases may be attributed to lifestyle factors such as: diet, obesity, alcohol and tobacco use.Moreover, the presence of oral <i>P. gingivalis</i> and <i>T. forsythia</i> has been found to be associated with an increased risk of esophageal cancer.Our review describes the role of <i>P. gingivalis</i> and <i>T. forsythia</i> in signaling pathways responsible for cancer development.It has been shown that <i>T. forsythia</i> may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α.Moreover, gingipain K produced by <i>P. gingivalis,</i> affects hosts immune system by degradation of immunoglobulins and complement system (C3 and C5 components).
|
30728854 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Minor allele of IL-6 rs1800797polymorphism decreased the risk of obesity/overweight in allelic 0.74 (0.59-0.92), dominant 0.65 (0.49-0.85), and over-dominant 0.66 (0.51-0.87) models.
|
31472475 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity and diabetes were associated with increased leptin and decreased adiponectin plasma levels, higher protein expression of leptin and IL-6 in SAT, and higher visfatin protein expression in EAT.
|
31533725 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05).
|
31365708 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Further, interventions that target both obesity and elevated levels of IL-6 are likely to be more effective than those focusing on only one.
|
29795469 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Maternal obesity is associated with alteration of immunological factors concentrations in the human milk, such as C-reactive protein (CRP), leptin, IL-6, insulin, TNF-Alpha, ghrelin, adiponectin, and obestatin.
|
31174304 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Insulin resistance, apoptotic marker M30, hs-CRP, and IL-6 were all elevated in adolescents with obesity.
|
31120986 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The increased levels of adipokines such as Leptin, IL-6 and TNF-α and decreased adiponectin were found among obese-T2DM, when compared to non-obese T2DM subjects.
|
30904536 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Ambient cold exposure partly normalizes the obesity-induced suppression of lPBN IL-6.
|
30865890 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In 209 patients with obesity a multiple regression model was computed with REE as the dependent variable and sex, waist, FFM, FM, homeostasis model assessment-insulin resistance (HOMA), interleukin-6 and High Density Lipoprotein-cholesterol as the independent variables.
|
31440209 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the C allele of rs1800796 and the C allele of rs2069849 of IL-6 gene interaction between rs1800796 and abdominal obesity were all associated with increased OST risk.
|
31301734 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several genetic variants are reported to be associated with obesity and hypo adiponectinemia, including ars1800796 polymorphism of the interleukin-6 (IL-6) gene.
|
30989422 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results were positively correlated in case of IL-6 with the body mass index the general accepted method used for the assessment of the obesity or overweight degree The determination of these markers in saliva samples by a stochastic method proved the utility within the medical examination for a better evaluation of the health status in obesity.
|
30605486 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results suggest that macrophage-driven IL-6 bridges obesity and osteonecrosis and inhibition of IL-6 or depletion of macrophage may represent a therapeutic strategy for obesity-associated osteonecrosis.
|
30779845 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity and diet composition were both positively associated to pro-inflammatory biomarkers, CRP and IL1b; while diet composition shared with physical activity levels the correlation with IL6 (positive with energy, fat, carbohydrate and saturated fatty acid intake, and negative with cholesterol intake and average physical activity in boys), NGF and glucose (in both cases correlations were negative with diet composition and physical activity variables) (P < 0.05, in all cases).
|
31787367 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obese-ALI animals, compared to Obese-SAL, exhibited increased interventricular septum thickness (<i>p</i> = 0.003) and posterior wall thickness (<i>p</i> = 0.003) and decreased pulmonary acceleration time to pulmonary ejection time ratio (<i>p</i> = 0.005); no changes in lung mechanics, IL-6, TNF-α, TGF-β, PCIII, and PCI in lung tissue; increased IL-10 levels in lung homogenate (<i>p</i> = 0.007); reduced MCP-1 expression in blood neutrophils (<i>p</i> = 0.009); decreased TNF-α expression in blood (<i>p</i> = 0.02) and BALF (<i>p</i> = 0.008) neutrophils; and increased IL-10 expression in monocytes (<i>p</i> = 0.004).
|
31275296 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The evaluation results of studies that controlled obesity indicate that periodontal therapy seems to have beneficial effects on IL-6 levels.
|
30543722 |
2019 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between -174G>C polymorphism in the IL-6 promoter region and the risk of obesity: A meta-analysis.
|
30113463 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The most appropriate prognostic indexes and associations were for hs-CRP, IL-6, and Hcy with abdominal obesity, waist circumference, WHtR, and wrist circumference, respectively.
|
30584444 |
2018 |