IL7R, interleukin 7 receptor, 3575

N. diseases: 231; N. variants: 41
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group BEFREE We set out to determine if decreased CD127 expression or impaired CD127 signaling may be the cause of Th17 impairment in HAART-controlled HIV infection. 30946152 2019
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 GeneticVariation group BEFREE Polymorphisms at α-chain of the IL-7 receptor (IL7R or CD127) gene are related to evolution of HIV-infection, but there are no data concerning the evolution of hepatitis C virus (HCV) infection. 26123260 2015
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 GeneticVariation group BEFREE The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection. 25421942 2015
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group BEFREE The downregulation of CD127 expression in HIV infection may be due to host (e.g. 22421574 2012
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 GeneticVariation group BEFREE Here, we explored whether the IL7 and IL7RA genetic polymorphisms were associated with the progression of HIV infection. 22329520 2012
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group BEFREE The expression of CD127 is significantly decreased in progressive HIV disease, whereas effective antiretroviral therapy results in its recovery. 21863001 2012
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group BEFREE Further elucidation of the mechanism(s) of CD127 downregulation will provide important insights into the immunopathogenesis of HIV disease. 21740271 2012
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group BEFREE These findings indicate that HIV infection alters IL-7 responsiveness of thymocytes by a mechanism other than CD127 downregulation and potentially explain the disruption in thymopoiesis observed in HIV infection. 21920046 2011
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group LHGDN CD4(+)CD127(-)CD25(-) T cells were not selectively resistant to HIV infection as levels of cell-associated virus were similar in all non-naive CD4(+) T cell subsets. 18390743 2008
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group BEFREE A better understanding of the factors regulating CD127 expression in HIV disease, particularly on T(CM) cells, might unveil new approaches exploiting the IL-7/IL-7R receptor pathway to restore T cell homeostasis and promote immune reconstitution in HIV infection. 18964017 2008
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 AlteredExpression group LHGDN Factors relevant to HIV infection that could potentially decrease CD127 expression on human CD8(+) T cells and the mechanisms by which this occurs were therefore evaluated. 17956896 2007
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.100 Biomarker group LHGDN HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro. 16614257 2006