CXCL8, C-X-C motif chemokine ligand 8, 3576

N. diseases: 1254; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease BEFREE A colorimetric microarray for the multiplexed detection of recurrence of bladder cancer including protein markers interleukin-8 (IL8), decorin (DCN), and vascular endothelial growth factor (VEGF) was established to enable easy and cheap read-out by a simple office scanner paving the way for quick therapy monitoring at doctors' offices. 29364182 2018
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease BEFREE Together, these results demonstrate the key roles of B cells within the bladder tumor microenvironment that increase the BCa metastasis and may help us to develop the potential therapies via targeting these newly identified IL-8/AR/MMPs signals to better battle the BCa progression. 26305549 2015
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease BEFREE TNF-α, IL-6 and IL-8 have been shown to be involved in the development and progression of various cancers, including bladder cancer. 23727622 2013
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 AlteredExpression disease BEFREE Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer. 22695075 2012
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease CTD_human Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells. 22015448 2012
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 GeneticVariation disease BEFREE IL-8 -251 T > A polymorphism is associated with bladder cancer susceptibility and outcome after BCG immunotherapy in a northern Indian cohort. 20470938 2010
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 AlteredExpression disease LHGDN Expression of angiogenesis-related genes regulates different steps in the process of tumor growth and metastasis in human urothelial cell carcinoma of the urinary bladder. 19096229 2008
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 AlteredExpression disease BEFREE These findings indicate that at the early stage of tumor growth, bFGF and IL-8 expression play important roles in the regulation of angiogenesis, tumorigenicity and subsequent metastases of human bladder cancer. 19096229 2008
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 GeneticVariation disease BEFREE Using the TaqMan method, we genotyped single nucleotide polymorphisms in interleukin (IL) -6 (-174 G-->C), IL-8 (-251 T-->A), tumor necrosis factor-alpha (TNF-alpha; -308 G-->A), and peroxisome proliferator-activated receptor gamma (PPARG; Pro12Ala), and determined their associations with BC initiation and clinical outcome. 16110031 2005
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease BEFREE Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8. 12855659 2003
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease LHGDN Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8. 12855659 2003
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease BEFREE Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8. 11496299 2001
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 AlteredExpression disease BEFREE Interleukin 8 expression regulates tumorigenicity and metastasis in human bladder cancer. 10786697 2000
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.400 Biomarker disease BEFREE In the present manuscript, we identify the factors constitutively produced by a human bladder cancer cell line (KU-19-19) that was found to produce beta human chorionic gonadotrophin (beta-hCG), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 1alpha (IL-1alpha), interleukin 6 (IL-6) and interleukin 8 (IL-8). 9231915 1997