CXCL8, C-X-C motif chemokine ligand 8, 3576

N. diseases: 1254; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype CTD_human Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line. 24795235 2014
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype CTD_human trans-resveratrol inhibits hyperglycemia-induced inflammation and connexin downregulation in retinal pigment epithelial cells. 20578705 2010
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype LHGDN Afa/Dr DAEC-induced IL-8 hyperproduction by PMN might thus be important for inducing and perpetuating local inflammation, and this self-amplifying loop might play a role in the pathogenesis of inflammatory bowel diseases such as Crohn's disease. 19015376 2009
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype LHGDN This study shows that PAD citrullinates the chemokine CXCL8, and thus may dampen neutrophil extravasation during acute or chronic inflammation. 18710930 2008
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 AlteredExpression phenotype LHGDN Elevation of circulating interleukin-8 is related to lymph node and distant metastases in esophageal squamous cell carcinomas--implication for clinical evaluation of cancer patient. 18182303 2008
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype LHGDN Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. 17680645 2007
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype LHGDN IL-8 and IFN-gamma in tear fluid of patients with cystic fibrosis. 16487026 2006
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype LHGDN Ghrelin may participate in the pathophysiology of colonic inflammation by inducing PKC-dependent NF-kappaB activation and IL-8 production at the colonocyte level. 16552751 2006
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype LHGDN Using a tumor xenograft model, we show that Ras-dependent CXCL-8 secretion is required for the initiation of tumor-associated inflammation and neovascularization. 15542429 2004
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 AlteredExpression phenotype LHGDN Abrogation of MRP-14 activity with a specific antibody also reduced the IL-8-stimulating potential of bronchial secretions, suggesting it was a significant stimulus to IL-8 production in the lung and may amplify the neutrophilic inflammation seen in bronchial disease. 12748056 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 AlteredExpression phenotype LHGDN Gastric mucosal cytokine responses in Helicobacter pylori-infected patients with gastritis and peptic ulcers. Association with inflammatory parameters and bacteria load. 12738388 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype LHGDN The observed association suggests that individuals with interleukin-8-251TT and interleukin-10-819TT, a combination presumably causing mild inflammation, have a higher probability of the continuing Helicobacter pylori infection, especially among current smokers. 12662377 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.400 Biomarker phenotype LHGDN Stimulation of conjunctival epithelium with proinflammatory mediators, TNF-alpha and/or IFN-gamma, generated the release of the chemotactic factors IL-8 and RANTES, which could act to prolong inflammation. 12792476 2003