CXCL8, C-X-C motif chemokine ligand 8, 3576

N. diseases: 1254; N. variants: 10
Disease: Hamman-Rich syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085786
Disease: Hamman-Rich syndrome
Hamman-Rich syndrome 		0.020 Biomarker disease BEFREE To search for single-nucleotide polymorphisms in the interleukin-8 (IL-8) and IL-8 receptor CXCR-1 and CXCR-2 genes, and to compare their distribution among patients with systemic sclerosis (SSc) with fibrosing alveolitis (FASSc) or without fibrosing alveolitis (NFASSc), or patients with cryptogenic fibrosing alveolitis (CFA), and normal healthy subjects. 10902769 2000
CUI: C0085786
Disease: Hamman-Rich syndrome
Hamman-Rich syndrome 		0.020 Biomarker disease BEFREE We suggest that IL-8 is a key factor in the pathogenesis of fibrosing alveolitis and that the poorer prognosis of CFA compared with FASSc is related to higher levels of IL-8 within the lower respiratory tract. 7735620 1995