|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Intriguingly, experimental results unravelled that excess O<sub>3</sub> promoted high expression of the pro-inflammatory cytokine interleukin-8 (IL-8), which ultimately induced depression phenotypes.
|
30997001 |
2019 |
|
Depressed mood
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Levels of IL-6 and -8 were analyzed in the CSF of 47 patients with relapsing-remitting MS. Correlations between IL-6 and IL-8 levels and self-rated depression and fatigue symptoms, as well as clinician-rated history of being exposed to interpersonal violence, were analyzed with correction for age, sex and MS disability status.
|
29324301 |
2018 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We found linear correlations between IL-1β, TNF-α, and IL-8, and the severity of depression, as well as between IL-8 and anxiety level in patients with comorbid anxiety disorder.
|
29856741 |
2018 |
|
Depressed mood
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Prevalent depression at baseline was significantly associated with higher contemporaneous levels of IL-1β and IL-8, independent of relevant covariates and after applying Bonferroni corrections.
|
29471232 |
2018 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
An inter-quartile range increase in distance-weighted vegetated land cover was associated with 37% (95% Confidence Limits 46%; 27%) reduced allostatic load; significantly reduced adjusted odds of having low level of norepinephrine, dopamine, and dehydroepiandrosterone, and high level of epinephrine, fibrinogen, vascular cell adhesion molecule-1, and interleukin-8 in serum, and α-amylase in saliva; and reduced odds of previously diagnosed depression.
|
28709033 |
2017 |
|
Depressed mood
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, we showed that FOXQ1 remarkably inhibited the replicative senescence through depressing the expression of the inflammatory cytokines interleukin-6 (IL-6) and IL-8 via modulation of SIRT1-NF-κB pathway.
|
28726780 |
2017 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Role of IL-8, CRP and epidermal growth factor in depression and anxiety patients treated with mindfulness-based therapy or cognitive behavioral therapy in primary health care.
|
28501736 |
2017 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
PSYGENET |
TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-life depression, while the significance of these associations was lost after Bonferroni correction.
|
25315113 |
2015 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
PSYGENET |
In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study.
|
22990943 |
2013 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The associations between physical disorders and incident depression were significant in the presence of 2 alleles related to higher proinflammatory cytokine production (tumor necrosis factor-α -850T and IL-8 -251A), and 1 allele related to lower anti-inflammatory cytokine production (IL-4 +33C).
|
22921153 |
2013 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
PSYGENET |
The associations between physical disorders and incident depression were significant in the presence of 2 alleles related to higher proinflammatory cytokine production (tumor necrosis factor-α -850T and IL-8 -251A), and 1 allele related to lower anti-inflammatory cytokine production (IL-4 +33C).
|
22921153 |
2013 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
PSYGENET |
Genetic variations in interleukin-8 and interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients.
|
23149083 |
2013 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Hyperglycemia and lipopolysaccharide decrease depression effect of interleukin 8 production by hypothermia: an experimental study with endothelial cells.
|
17898993 |
2008 |
|
Depressed mood
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Logistic regression analyses showed that after controlling for epidemiologic (age and sex), clinical (stage of disease, comorbidities), and symptom (depressed mood and fatigue) variables known to influence pain severity, variant alleles in IL-8 -251T/A [odds ratio (OR), 2.35; 95% confidence interval (95% CI), 1.10-5.03; P = 0.03] persisted as a significant factor for severe pain for White patients.
|
18086782 |
2007 |
|
Depressed mood
|
0.400 |
Biomarker
|
phenotype |
PSYGENET |
Logistic regression analyses showed that after controlling for epidemiologic (age and sex), clinical (stage of disease, comorbidities), and symptom (depressed mood and fatigue) variables known to influence pain severity, variant alleles in IL-8 -251T/A [odds ratio (OR), 2.35; 95% confidence interval (95% CI), 1.10-5.03; P = 0.03] persisted as a significant factor for severe pain for White patients.
|
18086782 |
2007 |