|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, our results indicated that IL-8 triggered ovarian cancer cells migration partly through Wnt/β-catenin pathway mediated EMT, and IL-8 may be an important molecule in the invasion and metastasis of ovarian cancer.
|
31793192 |
2020 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-6 and IL-8 as Prognostic Factors in Peritoneal Fluid of Ovarian Cancer.
|
31755326 |
2019 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Metformin interrupts bidirectional signaling between tumor and mesothelial cells by blocking OvCa cell TGF-β signaling and mesothelial cell production of CCL2 and IL-8.
|
31851935 |
2019 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-8 and IL-10 may be involved in the occurrence and development of ovarian cancer.
|
30719112 |
2019 |
|
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The addition of VEGF, IGF-1, and IL-8 weakened the inhibitory effect of DIRAS3 on ERK/AKT activity and reduced DIRAS3-mediated TFEB or FOXo3a nuclear localization and MAPLC3B expression in ovarian cancer cells.
|
30620384 |
2019 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Co-culture of ovarian cancer stem-like cells with macrophages induced SKOV3 cells stemness via IL-8/STAT3 signaling.
|
29656182 |
2018 |
|
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated intracystic cytokine levels, especially IL-6 and IL-8, are associated with worse prognosis in ovarian cancer.
|
28960399 |
2017 |
|
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, increased levels of IL-6 and IL-8 are associated with factors of worse prognosis in ovarian cancer.
|
28872976 |
2017 |
|
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, our data indicate that the induced CXCL8 expression may be responsible for the limited effectiveness of HDAC inhibitors in OC and perhaps other solid cancers characterized by CXCL8 overexpression, and suggest that targeting class I HDACs and CBP may provide novel combination strategies by limiting the induced CXCL8 expression.
|
29050320 |
2017 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, this study provides an alternative strategy of simultaneously targeting VEGF-A and IL-8 for combating OC.
|
26531153 |
2016 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma.
|
26267317 |
2015 |
|
Malignant neoplasm of ovary
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were noted in patients with the IL-8 +781 (T/T) genotype (p=0.0048) with increased frequencies of ovarian cancer, while women with the IL-8 +781 (C/C) allele suffer from ovarian cancer significantly less frequently (p=0.0003).
|
25151495 |
2015 |
|
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, modulation of IL-8 expression or its related signaling pathway may be a promising strategy for controlling the progression and metastasis of OVCA.
|
22579115 |
2012 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
CTD_human |
Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells.
|
21742513 |
2011 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
CTD_human |
Reciprocal regulation of 17beta-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer.
|
19401270 |
2009 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain reaction.
|
12668280 |
2003 |
|
Malignant neoplasm of ovary
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings provide important insights into the modulation of apoptosis by TRAIL and IL-8 in ovarian cancer.
|
12907626 |
2003 |
|
Malignant neoplasm of ovary
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of interleukin-8 and polarized epithelial expression of interleukin-8 receptor A in ovarian carcinomas.
|
10993102 |
2000 |