|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Th9 cells preferentially produce IL-9 and participate in allergic responses and asthma.
|
31776325 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-9 (IL-9) is a pleiotropic cytokine and was primarily studied in the context of T helper 2 (T<sub>H</sub>2)-associated immuno-pathological conditions such as asthma and parasitic infections.
|
31035677 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show that the levels of Th9 cells and their cytokine IL-9 in the peripheral blood of mice with bronchial asthma are significantly increased, suggesting that Th9 cells play important roles in the pathogenesis of asthma.
|
29456652 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Persistence of experimental asthma in ST2 KO mice was associated with an increase in levels of thymic stromal lymphopoietin (TSLP), IL-9, and IL-13, but not IL-5, in bronchoalveolar lavage fluid.
|
29132961 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9-producing Th9 cell is a novel Th cell subset involved in type II allergic inflammations such as asthma.
|
28477193 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to ascertain whether it is a successful translation from bench to bedside, the biological features of IL-9 were evaluated and up-to-date information regarding the role of IL-9 in different experimental murine models and human asthma were summarized.
|
28352305 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We observed that plasma IL-17A and IL-9 levels were significantly increased in asthmatics when compared with controls.
|
29138487 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytokine-producing Th subsets including Th1 (IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17), Th22 (IL-22), and T regulatory (IL-10) cells have all been suggested to play a role in the development of asthma.
|
28658556 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, loss of Foxo1 attenuates IL-9 in mouse and human Th9 and Th17 cells, and ameliorates allergic inflammation in asthma.
|
28993609 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cylindromatosis (Cyld) gene mutation in T cells promotes the development of an IL-9-dependent allergic phenotype in experimental asthma.
|
27372382 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study shows for the first time that IL-9 is involved in EO homeostasis in CRSwNP and could explain the low benefit of anti-IL-5 therapy for some patients with asthma and nasal polyposis.
|
25704963 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects with the dominant genotype for these IL9 polymorphisms were more likely to report a severe asthma exacerbation if exposed to increased dust mite levels.
|
25913104 |
2015 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In simple AD patients and AD patients complicated by allergic rhinitis or asthma, there were no significant differences in the Th9 cell percentage, PU.1 and IL-9 expression levels between them.
|
24032555 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the effects of IL-9, IL-13 and an IL-9/IL-13 combination, during differentiation of bronchial epithelial cells from normal (n = 6) and asthmatic (n = 8) children.
|
23671562 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9 targets cells of the lymphoid, myeloid and mast cell lineages, and is likely to contribute to the development of allergic and autoimmune diseases such as asthma, arthritis, multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
|
23291628 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This assumption was initially confirmed by functional analyses showing that both IL-9 and Th2 cells play an important role in the pathogenesis of asthma, IgE class switch recombination, and resolution of parasitic infections.
|
22235761 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 9 (IL-9) has been implicated in mast cell-related inflammatory diseases, such as asthma, where vascular endothelial growth factor (VEGF) is involved.
|
22413008 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD4(+) T-helper type 2 (T(H)2) cells, characterized by their expression of interleukin (IL)-4, IL-5, IL-9 and IL-13, are required for immunity to helminth parasites and promote the pathological inflammation associated with asthma and allergic diseases.
|
21841801 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genes encoding IL-9 and IL-9R have recently been implicated in the genetic basis of asthma and allergy.
|
21371865 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulated eosinophils in the airways in asthma may directly react with HDM and produce IL-9 to further promote Th2-type immune responses.
|
18349591 |
2008 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Approximately half of the Der f-specific Th clones derived from atopic asthmatics produced IL-9 upon TCR stimulation.
|
17541281 |
2007 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we examined the effect of IL-9 overexpression on the subepithelial fibrotic response, a feature of asthmatic remodeling, induced by chronic exposure to Alternaria alternata extract.
|
17446528 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD4+ lymphocytes are the principal source of IL-9 produced by PBMCs of adult atopic asthmatics.
|
17541282 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other activities described for IL-9 support its contribution to asthma and its important role in helminthic infections, where a Th2 response can be protective and IL-9 enhances resistance or is responsible for elimination of the nematode.
|
17177973 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was slight increased interaction effect on asthma between transmission of allele 122 of IL-9 gene to offspring and who were exposed to the fur of pets (OR = 3.33, P = 0.047).
|
16611254 |
2006 |