Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Immunofluorescence analysis of AQP1 siRNA treated tumours showed a significantly lower microvessel density.
|
23197380 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This article reviews the current understanding of AQP1-facilitated tumour development and progression with a focus on regulatory mechanisms and downstream signalling pathways.
|
28146084 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Intratumoural injection of AQP1 siRNA and CTRL siRNA was performed 10 days after tumour cell implantation.
|
29044946 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study evaluated the AQP1 protein expression in 78 melanoma patients, representing two predefined risk cohorts using the immune labeling technique with commercially available anti-AQP1 antibodies on routinely formalin-fixed and paraffin-embedded tumor tissue samples.
|
26848795 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Elucidation of the molecular mechanisms governing AQP1-mediated, estrogen-induced angiogenesis may contribute to an improved understanding of tumor development.
|
23450058 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
More importantly, AQP1 knockdown inhibited tumor growth in vivo and prolonged the survival time of nude mice.
|
26176849 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
AQP4 expressing glioma cells showed significantly reduced invasion compared to AQP1 and S180 expressing tumors as determined by quantitative stereology, consistent with a differential role for AQP1 and AQP4 in this process.
|
19761816 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Increasing evidences showed that aquaporin 1 played a role in tumor prognosis and diagnosis.
|
27143047 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The abnormal up-regulation of AQP1 in glial tumors suggests a potential pathological role for this membrane water channel and raises the possibility that selective AQP1 inhibition might offer a new therapeutic target for treatment of tumor-associated edema.
|
15670385 |
2005 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies have described important roles for AQP1 in epithelial carcinogenesis and tumor behavior.
|
30042826 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AQP1 expression and IMD was significantly correlated with tumor size, histologic grade, Child-Pugh classification, microvascular invasion and tumor-node-metastasis (TNM) stage (P<0.05).
|
29344137 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aquaporin-1 (AQP1) is a water channel protein expressed in vascular endothelia and involved in impaired angiogenesis in tumors.
|
17273788 |
2007 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The abnormal upregulation of AQP1 in certain glial neoplasms has suggested a potential role in tumor pathogenesis, apart from being a novel target for newer therapeutic regimen.
|
23361277 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, the AQP1 water channel is an excellent marker of microvasculature but it is heterogeneously expressed in different human tumors and not necessarily expressed in all neoplastic cells.
|
15809704 |
2005 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It was additionally observed that silencing of AQP1 expression resulted in in vivo inhibition of tumor growth, a decrease in the expression of invasion‑associated protein, and suppression of VM formation.
|
29257313 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aquaporin 1 and 3 were upregulated in cervical cancer compared to mild cervicitis and CIN2-3 (P<0.05); Tumor expression of aquaporin 1, 3 significantly increased in advanced stage disease, and patients with deeper tumor infiltration, lymph node metastases or larger tumor volume (P<0.05).
|
24918928 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Several recent studies have shown strong expression of AQP1 in proliferating tumor microvessels, suggesting that AQP1 may have an important role in tumor angiogenesis.
|
18275976 |
2008 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, aquaporin-1, possibly aquaporins-3 and -5, and GLUT-3 message appeared upregulated in the tumors.
|
11161003 |
2001 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AQP1 promoter hypomethylation is common in ACC, and AQP1 tends to be overexpressed in these tumors.
|
24493792 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Twenty tumour bank specimens were subject to Western blot analysis and quantitative polymerase chain reaction (PCR) to determine the expression of AQP1 and 4.
|
20965731 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased glucose metabolism at the tumor periphery may provide a scenario by which upregulation of AQP1, LDH, and cathepsin B contributes to acidification of the extracellular milieu and to invasive potential of glioma cells in perivascular space.
|
17898873 |
2007 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of AQP1 in cell lines was assessed by quantitative (q) PCR, western blot and immunofluorescence, while expression of AQP1 in human colon tumour tissue was assessed by immunohistochemistry.
|
26912239 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aquaporin-1 (AQP1) is a glycoprotein that mediates osmotic water transport, its expression has been found to correlate with tumour stage in some tumours.
|
22415096 |
2012 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Renal tumour subtype/nephron segment-specific gene expression detected by RQ-PCR demonstrated that the tumour expressed relatively high amounts of alpha-methylacyl-CoA racemase (AMACR) and the KIT oncogene, but relatively low amounts of carbonic anhydrase IX (CA9), aquaporin 1 (AQP1), claudin 7 (CLDN7), parvalbumin (PVALB), chloride channel Kb (CLCNKB) and 11-beta-hydroxysteroid dehydrogenase 2 (HSD11B2), suggesting diverse mRNA signatures.
|
17323425 |
2007 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Poor differentiation of tumor cells and non-clear cell-subtype RCC were significantly associated with low levels of aqp1 transcripts.
|
9495349 |
1998 |