Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
IL-10 production is increased in RA, SS, and SLE.
|
7980676 |
1994 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
IL-10 overproduction in SLE suggests that this Th2-type interleukin plays a role in the production of autoantibodies through pathways involving both paracrine production by monocytes and autocrine IL-10 production by autoreactive B cells.
|
8186374 |
1994 |
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate herein that the accelerated development of lupus-like autoimmune disease in MRL-lpr/lpr and MRL.Yaa mice, as compared with MRL-lpr/lpr.ll and MRL-+/+ mice, respectively, was correlated with an enhanced expression of IFN-gamma vs IL-4 and IL-10 mRNA in CD4+ T cells, which paralleled with an increase of spontaneous and foreign T cell-dependent antigen-induced productions of IgG2a and IgG3 vs IgG1 antibodies.
|
8601623 |
1996 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The transcripts of interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) genes of these two T cell lines were evidently increased in the presence of SLE sera, while IL-2 and IL-4 were unaffected.
|
9010506 |
1997 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We studied two novel polymorphic dinucleotide repeats in the IL-10 promoter region (IL10.G and IL10.R) in order to investigate their possible significance in association with this condition in a group of 56 Caucasian SLE patients compared with 102 ethnically matched controls.
|
9234486 |
1997 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The dysregulation of IL-10 production previously identified in SLE patients is also present in healthy members of families with several cases of SLE, and it may contribute to the immunologic abnormalities affecting relatives of SLE patients.
|
9259422 |
1997 |
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Polymorphisms within the IL-10 gene promoter that are associated with high IL-10 levels may be important in the development of certain clinical features in SLE.
|
9415634 |
1997 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that individuals carrying specific genotypes of both bcl-2 and IL-10 are at significant risk of developing SLE.
|
9550468 |
1998 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, IL-10 genotypes are strongly associated with certain clinical manifestations of SLE and may have a role in predicting disease prognosis.
|
9627019 |
1998 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Universally binding nucleosomal epitopes are productively recognized by autoreactive T cells by binding to the T-cell receptor-alpha chain; (b) circulating T cells from patients with lupus commonly display a deficiency of the T-cell receptor zeta chain, and upon ligation of their cell-surface antigen receptor overproduce tyrosine phosphorylated proteins; (c) lupus and lupus nephritis are associated with a low-binding FcgammaRIIIA (CD16) polymorphism that crosses ethnic barriers; (d) the pathogenetic role of the cytokine interleukin-10 is expanding, because it is reportedly overproduced not only by cells from lupus patients but also by cells from their healthy relatives, and its overproduction in vitro is correlated with increased apoptotic cell death and with lymphopenia.
|
9746856 |
1998 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic analysis of interleukin-10 promoter region in patients with systemic lupus erythematosus in Taiwan.
|
9819501 |
1998 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In human SLE, genes of early components of complements as well as many polymorphic genes (including the MHC class II and class III, FcgammaR, mannose-binding protein, IL-6, Bcl-2, and IL-10 genes) have been associated with SLE or LN by population-based case-control or within-case studies.
|
9884094 |
1998 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The IL10 locus is associated with neuropsychiatric manifestations in SLE.
|
10343522 |
1999 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
These data support the hypothesis that IL-10 production may be genetically determined, and may predispose one toward development of SLE.
|
10446864 |
1999 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The present study was designed to determine whether deficiency of IL-12 and excess production of IL-10 and IL-6 in systemic lupus erythematosus (SLE) are due to aberrant regulation at the gene level.
|
10525320 |
1999 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results do not support that the IL10 gene contributes to the susceptibility to SLE in the populations we studied.
|
10529131 |
1999 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus.
|
10556270 |
1999 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Of the 7 candidate genes tested, only IL-10 was significantly associated with SLE in Italian patients.
|
10643707 |
2000 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis.
|
10712664 |
2000 |
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The development of SLE-like symptoms and SLE-related autoantibody production was observed more commonly than expected, with an increased risk in patients with SLE-related HLA haplotypes, increased serum IL-10 levels and ANA in speckled patterns.
|
10952745 |
2000 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
High innate IL-10 production underlies susceptibility for systemic lupus erythematosus but not the severity of the disease.
|
10979237 |
2000 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this experimental setting, we also demonstrated that IL-10-containing SLE PBMC supernatants inhibited IL-12 p35 and IL-12 p40 gene expression.
|
11014347 |
2000 |
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings support the hypothesis that the enhanced production of IFN-gamma by mononuclear cells may trigger inflammatory responses, together with the enhanced production of IL-10 resulting in autoantibody production by B cells in human SLE.
|
11122256 |
2000 |
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that TNF-alpha and IL-10 gene polymorphisms are associated with the production of those cytokines and the development of graft failure after organ transplantation and systemic lupus erythematosus.
|
11223972 |
2000 |
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that the histone deacetylase inhibitor, trichostatin A, significantly down-regulated CD154 and IL-10 and up-regulated IFN-gamma gene expression in SLE T cells.
|
11226290 |
2001 |