IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Interleukin-10 mRNA expression was significantly enhanced in AD compared with control subjects (P < .05). 10831012 2000
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Interleukin-10 haplotype associated with total serum IgE in atopic dermatitis patients. 16076299 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis. 16185274 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE IL-10 promoter polymorphisms are associated with the phenotype of AD in children. 17188628 2007
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE IL-10 production was significantly decreased in the supernatants from both the HCs and patients with AD after CRH treatment. 22000570 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE After adjusting for multiple tests, the association between IL13 130 and IgE and the interactive effects of IL10-1082 on current rhinitis and IL8 781 on atopic eczema were significant by controlling a false-positive rate of 0.05 and 0.10, respectively. 21749458 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis. 23857017 2014
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE FLG mutation, alone and in combination with certain IL-10 or IL-13 polymorphisms, enhances the risk for the development of AD in the Polish population. 21426411 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Having a dog in infancy is associated with higher IL-10 and IL-13 cytokine secretion profiles and reduced allergic sensitization and atopic dermatitis. 14767447 2004
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE In our study, genotypes of 7 polymorphisms--LL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P < .05). 22533231 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Increased lipopolysaccharide-induced tumour necrosis factor-alpha, interferon-gamma and interleukin-10 production in atopic dermatitis. 17596153 2007
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Interestingly, IL-10 mRNA expression by purified T cells of children with allergic and non-allergic asthma and children with atopic dermatitis was strongly decreased as compared with that of healthy controls. 9199877 1997
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with Bifidobacterium Colonization. 30205386 2019
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Moreover, ICOS<sup>+</sup> Tregs showed reduced production of interleukin-10, suggesting impaired immunosuppression in AD. 30515983 2019
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Mothers who had atopic dermatitis had significantly decreased levels of IL-10 (p = 0.044) in breast milk. 23980846 2013
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Our findings indicate a potential role of IDEC-like in the maintenance of inflammation in atopic dermatitis patients; moreover, IDEC-like may exert a regulatory impact on T cells of AD individuals through IL-10, often induced by agonist mimicking single stranded RNA virus. 28083892 2017
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Our results demonstrate for the first time that IL-10 receptors may have a role in the pathogenesis of atopic eczema and its upregulation by FK506 and UVA could explain the therapeutic efficacy of these agents. 10563471 1999
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Our results showed that ozonated oil could suppress inflammation in an AD murine via decreasing Th2-dominant cytokines response and increasing IL-10 expression. 29466894 2018
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease CTD_human Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. 18249437 2008
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Polymorphisms in the genes encoding tumour necrosis factor-alpha (TNFA-238 G/A, -308 G/A), interleukin (IL)-1beta (IL1B-511 T/C, +3953 T/C), IL-6 (IL6-174 C/G), IL-10 (IL10-1082 A/G) and the IL-1 receptor antagonist (IL1RN intron 2) were investigated in German patients with AD (n = 94) and in healthy nonatopic individuals (n = 214) by polymerase chain reaction-based methods and direct cycle sequencing. 12828754 2003
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Protective cytokine polymorphisms for AD for seven cytokine genotypes (IL-4 -1098/G:T, TGFbeta cdn25/G:G, IL-4 -33/C:C, IL-1alpha -889/C:C, IFNgamma +874/A:A, IL-10 -1082/A:A, IL-1beta -511/C:C), one cytokine diplotypes, two cytokine haplotypes, and four cytokine alleles were also found. 22427475 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE SNPs at positions -3575, -2849, -2779, -2763, -1082, -851, -819 and -592 in the IL10 promoter region were genotyped in individuals with atopic dermatitis (n= 47) and nonatopic control subjects (n= 40) using polymerase chain reaction-based techniques and induced heteroduplex generator (IHG) analysis. 19552724 2009
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE The allele and genotype frequencies of genes encoding for IL-10 and TGF-β1 were investigated in 89 patients with atopic dermatitis in comparison with 138 in the control group using the PCR-SSP method. 29310944 2018
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE The current evidence does not support a strong genetic relationship between IL-10 -1082 A/G, - 819 T/C and - 592 A/C polymorphisms and the susceptibility to atopic dermatitis. 31101031 2019
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE The increased level of SP, in atopic dermatitis, induces the release of interferon (IFN)-γ, interleukin (IL)-4, tumor necrosis factor (TNF)-α, and IL-10 from the peripheral blood mononuclear leukocytes. 29713744 2018