|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results suggest that IL-10 released by mesenchymal cells in inflammatory arthritis can modulate synovial inflammation and joint destruction by paracrine and/or autocrine mechanisms.
|
11327238 |
2001 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
To gain insight into IL-10 responses in inflammatory arthritis, we used microarray analysis to determine the patterns of IL-10-inducible gene expression in freshly isolated RA and seronegative SpA synovial macrophages.
|
16947381 |
2006 |
|
Arthritis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Increment in the level of IL-10 in the combination group could be positively correlated with the recovery of arthritis.
|
28326455 |
2017 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated that anti-inflammatory cytokine IL-10 was a critical mediator for PGRN-mediated anti-inflammation in collagen-induced arthritis by using PGRN and IL-10 genetically modified mouse models.
|
28011648 |
2017 |
|
Arthritis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
A single intraperitoneal injection of human IL-10 expression plasmid complexed with liposomes 2 to 4 days after the onset of arthritis was sufficient to give significant and prolonged amelioration of arthritis for 30 days.
|
10849557 |
2000 |
|
Arthritis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that local over-expression of IL-10 in the knee joint of mice regulates the expression of collagen arthritis, probably through down-regulation of TNF-alpha.
|
10792391 |
2000 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interleukin-10 (IL-10) produced by butyrate-induced expanded T<sub>reg</sub> cells was critical, as treatment with butyrate did not affect inflammatory arthritis in IL-10-knockout mice.
|
30034392 |
2018 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Efficacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen-induced arthritis.
|
12539154 |
2003 |
|
Arthritis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition, administration of PF (5, 10 and 20 mg/kg/day) for 28 days markedly exhibited an anti-arthritic activity by offsetting the body weight loss, inhibiting the paw edema, reducing the arthritis scores and the indices of thymus and spleen, inhibiting the expression levels of TNF-α, IL-1β, IL-6, COX-2 and 5-LOX, and increasing the expression of IL-10, when compared with the respective control group in CFA-induced arthritis assay.
|
28352356 |
2017 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Finally, we showed a strong correlation between APRIL and IL-10 in the inflamed synovial tissue of inflammatory arthritis patients.
|
31258536 |
2019 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our previous work showed that under inflammatory condition MZ B-cells differentiated into IL-10 producing cells and contributed to the downregulation of collagen-induced arthritis, while follicular B-cells failed to do so.
|
31216428 |
2019 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
APL-2, an altered peptide ligand derived from heat-shock protein 60, induces interleukin-10 in peripheral blood mononuclear cell derived from juvenile idiopathic arthritis patients and downregulates the inflammatory response in collagen-induced arthritis model.
|
24474501 |
2015 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Conversely, Sm infection did not affect the exacerbated arthritis in IL-10 KO mice, although IL-17A production was reduced by the helminth.
|
30194773 |
2019 |
|
Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we show that injection of an adenoviral vector carrying the IL-10 gene into a single paw can suppress development of arthritis in other, noninjected paws of the same individual.
|
10092823 |
1999 |
|
Arthritis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that TOV has significant anti-arthritic effects on collagen-induced arthritis in rats, which may be attributed to the inhibition of the levels of IL-1β, IL-6, IL-8, IL-17A, TNF-α, MMP-3 and MMP-9, and the increase of IL-10 in serum as well as down-regulation of the protein expression of COX-2 and iNOS in synovial tissues via suppressing the phosphorylation and degradation of IκB.
|
30831463 |
2019 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our data identify a novel role for FoxO1 in regulating IL-10 secretion during classic activation and highlight the potential for therapeutic interventions for chronic inflammatory conditions, such as atherosclerosis, diabetes, inflammatory bowel disease, and arthritis.
|
25420919 |
2015 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our work demonstrated that EEC possessed the potential therapeutic effect against arthritis in rodents which was attributed to modulating proinflammatory cytokines TNF-α, IL-1β and anti-inflammatory factors IL-10.
|
29753098 |
2018 |
|
Arthritis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis.
|
16704745 |
2006 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results suggest that IL-10 limits the development of joint inflammation in both arthritis-resistant and -susceptible mouse strains infected with B. burgdorferi and that increased IL-10 production cannot rescue genetic susceptibility to development of pathology in this model.
|
18824530 |
2008 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Viral IL-10 and soluble TNF receptor act synergistically to inhibit collagen-induced arthritis following adenovirus-mediated gene transfer.
|
10640777 |
2000 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Disease-dependent local IL-10 production ameliorates collagen induced arthritis in mice.
|
23166758 |
2012 |
|
Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Individuals with IL-10 receptor mutations also experience cutaneous folliculitis and arthritis.
|
25004811 |
2014 |
|
Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine the distribution of the interleukin-10 (IL-10) 5' flanking region haplotypes in children with arthritis and in controls, and to investigate the functional significance of each haplotype.
|
10366102 |
1999 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
DBA/1 mice doubly deficient in IL-4 and IL-10 were used to confirm that these two cytokines are important for the APL-induced attenuation of arthritis.
|
27837109 |
2016 |
|
Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL-17 deficiency ameliorated disease symptoms of inflammatory arthritis in IL-1RaKO mice by suppressing the frequency of plasma cells and antibody production while enhancing the frequency of IL-10-producing B cells.
|
29803636 |
2018 |