Numerous studies have uncovered the association of Interleukin-10 (<i>IL-10</i>) gene rs1800896 polymorphism with the risk of prostate cancer (PCa); however, their conclusions were inconsistent.
The suppression of inflammation by testosterone were observed in patients with coronary artery disease, prostate cancer and diabetes mellitus through the increase in anti-inflammatory cytokines (IL-10) and the decrease in pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α).
We used RNA <i>in situ</i> hybridization to localize IL1β, IL6, IL8, and IL10 mRNA in low- and high-grade prostate cancer from African American and European American men.