Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study evaluated the possible association between SNPs in cytokines coding genes, namely IL10, IL6 and IFNG, cytokines serum levels and clinical assessment' scores in patients with Rheumatoid Arthritis(RA).
|
31494241 |
2020 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In activated macrophages, N-PD decreased levels of pro-inflammatory cytokines, while N-CU increased levels of anti-inflammatory IL-10, and N-PD/CU exhibited best therapeutic effect in vitro, suggesting co-delivery of PD and CU may synergistically control the course of RA.
|
31819422 |
2019 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Whereas, CM3D was characterised by a prevailing expression of anti-inflammatory cytokines such as IL-10 and LIF, along with trophic factors involved in different mechanisms leading to tissue regeneration, such as PDGF-BB, FGF-2, I-309, SCF, and GM-CSF; CM2D presented relatively higher levels of IL-6, MCP-1, and IL-21, with recognised pro-inflammatory roles in joint disease and pleiotropic effects in the progression of rheumatoid arthritis (RA).
|
30804924 |
2019 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Administration of VIP inhibited experimental RA in rats through restoring the IL-10 expression in RegMos.
|
30636174 |
2019 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The proinflammatory IL-12 as well as anti-inflammatory IL-10 and IL-1RA were significantly (p<0.05) upregulated in the plasma of RA patients compared to normal controls.
|
29998825 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, in vivo biodistribution and arthritis targeting of radiolabeled F8-IL10 were investigated in RA patients, followed by further animal studies.
|
30550295 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In summary, our present study demonstrated that down-regulation of miR-98 inhibited the proliferation and promoted the apoptosis of TNF-α-stimulated HS partly by targeting IL-10 and regulating NF-κB signaling pathway, insinuating miR-98 as a candidate biomarker in RA.
|
31077735 |
2019 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This paper corroborates the idea of a correlation between sex, IL-10 polymorphisms and RA, which should be studied in depth, since recent papers have shown that IL-10 injected into joints seems to decrease inflammation.
|
28691456 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL4-10 fusion protein is a novel drug, signalling cells to induce immunoregulatory activity that overcomes limitations of IL-4 and IL-10 stand-alone therapy, and therefore has therapeutic potential for inflammatory diseases such as rheumatoid arthritis.
|
30307604 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-10 deregulation plays a role in the development of a large number of inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergy.
|
28799796 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The AUC of IL-10 for diagnosing RA was 0.671, with a 95% confidence interval of 0.602-0.741 and a cut-off value of 87.315.
|
30915732 |
2019 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The level of IL-17 increased with the increase of synovial inflammation in the rheumatoid arthritis-induced rats, and the level of IL-10 increased as the inflammation subsided, which shows that both cytokines are related to the occurrence and development of rheumatoid arthritis and its inflammation.
|
30574751 |
2019 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
TAN had therapeutic effects on RA by decreasing the oxidative stress damage and regulating inflammatory cytokine expression, including suppression of the accumulation of MDA products, decreasing the IL-1β, TNF-α, IFN-γ, and PGE2 levels, enhancing the IL-10 and the activity of antioxidant enzymes, which was through upregulating Nrf-2 signaling pathway.
|
31344704 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cytokine-mediated processes such as the activation of T helper 2 cells by IL-4 and IL-13, the resolution of inflammation by IL-9, IL-5-induced eosinophil expansion, IL-33-mediated macrophage polarization, the production of IL-10 by regulatory B cells and IL-27-mediated suppression of lymphoid follicle formation are all involved in governing the regulation and resolution of inflammation in RA.
|
30341437 |
2019 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IL-10 mRNA levels in LPS-treated RASFs were moderately increased by pretreating cilostazol (1-10 μM) or celecoxib (10-50 μM) monotherapy, but 3 μM of cilostazol add-on for 30 μM celecoxib treatment synergistically increased IL-10 mRNA levels and IL-10 release to culture media.
|
31123968 |
2019 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The in vitro study using fibroblast-like synovial cells cultured in synovial fluid, demonstrated the ability of these vesicles to downregulate the production of anti-apoptotic proteins IAP1 and IAP2 and stimulate the production of IL-10, while the production of IL-6 and IL-15 and reactive oxygen species was reduced, confirming their suitability in counteracting pathogenesis of rheumatoid arthritis.
|
30659893 |
2019 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis showed the interleukin-10-1082G>A, -592C>A, and -819C>T polymorphisms are correlated with the susceptibility to RA.
|
30328021 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
MDSCs could reciprocally regulate Th17/Treg cells and suppress CIA via IL-10, suggesting that MDSCs might be a promising therapeutic strategy for T cell mediated autoimmune diseases including RA.
|
29491381 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We further found out the concentration of IL-6, IL-8, IL-10 and MCP-1 was higher in their synovial fluid which may mediate neutrophil autophagy in RA via cytokine-cytokine receptor interaction and IL-17 signaling pathway.
|
30312880 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The roles of these cytokines are different in RA and lupus, as high IL-10 in RA is associated with increased depressive symptoms, but high IL-10 in the lupus patients is associated with decreased depression.
|
30148175 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
RESULTS Serum levels of sST2, IL-33, and pro-inflammation cytokine IL-17 were all up-regulated, while the immunosuppressive cytokine IL-10 was decreased in RA patients.
|
29798971 |
2018 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The serum IL-10 levels are increased in RA patients.
|
29621504 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
ROS/TLR4- coupled activation resulted in the release of HMGB1, TNF-α, IL-1β, and IL-10 in conjunction with upregulation of myeloid-related protein (MRP8/14) inflammatory markers that may contribute to the RA pathophysiology.
|
30254017 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Correlation analysis between RDW and CRP, ESR, TNF-α, IL-6, and IL-10 in RA was conducted by Microsoft Excel.
|
29101675 |
2018 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Contrary to CDKN1A silencing, CDKN1A over-expression significantly inhibited the proliferation and invasion of HFLS-RA, arrested HFLS-RA in G0/G1 phase and down-regulated the expressions of tumour necrosis factor (TNF)-α and interleukin (IL)-6, while it up-regulated the expression of IL-10.
|
29920650 |
2018 |