IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.500 AlteredExpression disease BEFREE Compared to healthy controls, B10 cell percentages in T1D were significantly lower (5.6±3.5% vs. 6.9±3.3%; P <0.05), produced less IL-10 (15.4±4.3% vs. 29.0±4.5%; P <0.001), and lacked regulatory capacity. 31849037 2020
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE This vaccine immunized into prediabetic NOD mice subcutaneously could induce IL-10 and TGF-β expressing pTregs and lead to suppressing autoreactive T cells responses, resulting in the prevention of T1D in these animals. 31070990 2020
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Taken together, our results suggest that IL-10 is important for promoting osteoblast maturation and reducing bone loss during early stages of T1D. 31538345 2020
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE However, addition of anti-IL-7Rα antibodies to peptide/alum vaccination unexpectedly increased non-specific IFN-γ, IL-2 and IL-10 cytokine production and did not result in improved prevention of T1D onset. 30908554 2019
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Cytokines such as interleukin (IL)-4, IL-10, and transforming growth factor (TGF)-β also play an important role in protection from T1D. 30758662 2019
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE IL-10 deregulation plays a role in the development of a large number of inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergy. 28799796 2019
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE We show that natural protection from type 1 diabetes in nonobese diabetic (NOD) mice is associated with increased numbers of IL-10-producing B cells, while development of type 1 diabetes in NOD mice occurs in animals with compromised IL-10 production by B cells. 31728048 2019
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE After stimulation, the percentage of resting Tregs was decreased and that of effector/memory Tregs was increased in both healthy controls and T1D patients, but CD39 expression on effector/memory Tregs was still lower and there was no increase in IL-10 secretion in T1D patients. 30318734 2019
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Type-I Interferons Inhibit Interleukin-10 Signaling and Favor Type 1 Diabetes Development in Nonobese Diabetic Mice. 30061883 2018
Diabetes Mellitus, Insulin-Dependent
0.500 AlteredExpression disease BEFREE A significant increase in the levels of interleukin-4 (IL-4), IL-10, and transforming growth factor-β, and a decrease in the levels of IL-17 and interferon-γ in concordance with the significant increase in the Treg cell ratio in splenic MNCs (P < 0.05) was shown in T1DM mice treated with AD-MSC's exosomes as compared to T1DM untreated mice. 30074271 2018
Diabetes Mellitus, Insulin-Dependent
0.500 AlteredExpression disease BEFREE Out of 75 T1DM patients, 36 were males with Mean ± SD age 22.3 ± 5.2 years, IL-6, TNF-α and IL-10 were significantly higher (P < 0.05) in T1DM patients as compared to controls. 30155878 2018
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE This suggested that T1DM susceptibility in Nod2<sup>-/-</sup>NOD mice is dependent on the alteration of gut microbiota, which modulated the frequency and function of IgA-secreting B-cells and IL-10 promoting T-regulatory cells. 28592385 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE IL-10 and IL-12 were both positively associated with T1D risk in the model 2 (RC, 1.19, P=0.006 and 1.07, P=0.02, respectively)-these results were borderline significant in model 1, but showed the same direction as the results from model 2. 27871914 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Comparisons between populations showed increased levels of haemoglobin A1c (HbA1c), C-reactive protein (CRP), nitric oxide (NO), glutamic acid decarboxylase and insulin and islet cell autoantibodies [glutamic acid decarboxylase autoantibodies (GADA), insulin autoantibodies (IAA) and islet cell cytoplasmic autoantibodies (ICA), respectively], interferon (IFN)-γ, tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IL -10, IL -12, IL -17, C3d and sC5-9 in T1D-EV<sup>+</sup> versus T1D-EV<sup>-</sup> . 28640379 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The combined effect of anti‑CD20 and IL‑10 on immune function of mice with T1D remains unknown. 28765956 2017
Diabetes Mellitus, Insulin-Dependent
0.500 AlteredExpression disease BEFREE Proportion of responders , as well as levels of secreted IL-10, were significantly higher in LADA than T1DM group, following stimulation with both insulin (P=0.01) and GAD65 (P=0.03). 29067979 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Fas ligand drives insulitis in the non-obese diabetic mouse model of type 1 diabetes (T1D) and negatively regulates IL-10-producing (IL-10<sup>pos</sup>) CD5<sup>+</sup> B cells in pancreata. 28439273 2017
Diabetes Mellitus, Insulin-Dependent
0.500 AlteredExpression disease BEFREE Following STZ treatment to induce T1D, NLRP3-deficient mice also exhibited an increase in myeloid-derived suppressor cell and mast cell numbers in the PLNs along with a significant increase in IL-6, IL-10, and IL-4 expression in the pancreatic tissue. 28289409 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE We studied helper T-lymphocyte reactivity against β-cell autoantigens by measuring production of the pro-inflammatory cytokine interferon-γ and the anti-inflammatory cytokine interleukin-10, using enzyme-linked immunospot assays in 61 people with Type 1 diabetes (within 3 months of diagnosis, positive for HLA DRB1*0301 and/or *0401), of whom 33 were children/adolescents, and a further 91 were unaffected siblings. 27151105 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE NOD mice receiving transient BAFF blockade were characterized by an enrichment of regulatory B lymphocytes that inhibit T1D development through IL-10 production, but this population is sensitive to deletion by anti-CD20 treatment. 29055002 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Higher levels of proinflammatory mediators (IL-17C and BD-2) in the absence of similar changes in mediators associated with homeostasis (interleukin 10 and thymic stromal lymphopoietin) were also observed in T1D-derived primary IEC cultures. 28119693 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Our data suggested that SGAD65190-315 /IL-10 DNA vaccine had protective effects on T1D by upregulating autoantigen-reactive Tregs. 26797873 2016
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE However, the Treg cells showed a decreased production of anti-inflammatory (IL-10, IL-35, TGF-β) and increased pro-inflammatory (IFN-γ, IL-2, IL-17) cytokines, indicating a phenotypic shift of Treg cells under T1D condition. 26224624 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Likewise, healthy individuals showed increased frequencies of both CD40(+) and IL-10(+) B cells compared to T1D patients. 25187361 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE T cells secreting the cytokines IFN-γ and IL-10 in response to seven peptides known to elicit T cell responses in type 1 diabetes were quantified by cytokine ELISPOT in HLA-typed patients characterized for Abs to IA-2 epitopes. 25225671 2014