|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, these results show that IL-10 secreted from local plasmacytoid dendritic cells promotes endometriosis development through pathological angiogenesis during the early disease stage.
|
31418859 |
2019 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
M-MDSCs from EM PBMCs inhibited proliferation and activity in autologous T cells. rhCCL25 promoted IL-10 and GM-CSF secretion and arginase enzymatic activity in CD33<sup>+</sup> CD14<sup>+</sup> CD11b<sup>+</sup> HLA-DR<sup>-</sup> M-MDSCs.
|
30375700 |
2019 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.
|
30579999 |
2019 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The serum and peritoneal fluid levels of IL-1β and IL-10 were not statistically significantly different between the endometriosis and control groups.
|
30632819 |
2019 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Compared to endometriosis group, IFNγ, IL-7, and IL-15 were observed to be significantly higher in the PF of the control group, and IL-10 was lower in the control group (p < 0.05).
|
30712043 |
2019 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, IL-2 concentration was significantly higher in peritoneal fluid (PF) in the endometriosis group (p = .0034), IL-10 concentrations in PF were significantly lower in the early-stages of endometriosis than in the more advanced groups (p = .0439), and IL-4 concentration in PF was significantly higher in more advanced endometriosis (p = .0228).
|
29308924 |
2018 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In endometriosis, TGF-β could affect differentiation of T helper (Th) cells, hence produce more IL-17 and IL-10 to PF and might have an indirect influence on inflammation, which is associated with higher IL-1β and IL-6 levels.
|
30367890 |
2018 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Exposure with anti-IL-10 receptor β neutralizing antibody (αhIL-10Rβ) or αTGF-β could partly reverse these effects of ESCs and macrophages on NK cells <i>in vitro</i> These results suggest that the interaction between macrophages and ESCs downregulates cytotoxicity of NK cells possibly by stimulating the secretion of IL-10 and TGF-β, and may further trigger the immune escape of ectopic fragments and promote the occurrence and the development of EMS.
|
28971893 |
2017 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The present study investigated the differentiation mechanism and role of IL-10-producing Th17 cells in endometriosis.
|
28300844 |
2017 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs498679 (TLR4 gene), rs1799964 (TNF-α gene), rs3024496 (IL-10 gene), neither when comparing endometriosis subgroups (I-II versus III-IV).
|
28470452 |
2017 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that IL-10 592A/C and 819T/C promoter polymorphisms confer susceptibility to advanced endometriosis.
|
28004192 |
2017 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, no associations were found between the IL-10 -1082 A/G and -819 T/C polymorphisms and susceptibility to endometriosis.
|
23237776 |
2013 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
our results suggest that the IL-10 ACC/ACC genotype, which is known to be a ‘low-producer’ of IL-10, is associated with endometriosis.
|
20618176 |
2011 |
|
Endometriosis
|
0.600 |
Therapeutic
|
disease |
RGD |
The aim of this study is to investigate the effect of clarithromycin, one of the major macrolides, and telithromycin, one of the antibiotics belonging to a macrolide group (ketolide), on IL6, IL10 and Ccl2 expression in a rat endometriosis model induced by the surgical transplantation of endometrium onto the peritoneum in 8-week-old female Sprague-Dawley rats.
|
21665488 |
2011 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model.
|
21705369 |
2011 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-10 attenuates TNF-alpha-induced IL-6 synthesis via NF-kappaB and MAPK pathways in endometriotic cells.. Interleukin-10 may play a significant role in the pathogenesis of endometriosis.
|
18684450 |
2009 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Case-control study to investigate the association between endometriosis and four inflammation-related genes: interleukin (IL)-6, IL-10, IL-1 beta, and cyclooxygenase-2.
|
18930197 |
2009 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The X allele of ERalpha-XbaI and the -592 or -819 C allele of IL-10 are associated with endometriosis.
|
18687423 |
2009 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
In contrast, the percentages of CD14+ cells producing TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 were significantly higher in PB than PF of women with endometriosis.
|
17207568 |
2008 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
There were no significant differences in the genotype and allele frequencies of IL-10 gene promoter polymorphisms at position -1082 between the endometriosis and the control groups.
|
17178764 |
2007 |
|
Endometriosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increased frequency of -819 or -592 C allele and increased protein production of IL-10 in PF in patients with endometriosis compared with controls and correlations of polymorphisms at -819 and -592 sites with protein levels of IL-10 in PF in patients with endometriosis may suggest that polymorphisms at -819 and -592 sites and their protein production are associated with endometriosis risk.
|
17178764 |
2007 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Consistent with these data, enzyme-linked immunosorbent assay showed that moderate to severe endometriosis was associated with markedly elevated levels of IL-10 in the peritoneal fluid.
|
12700072 |
2003 |
|
Endometriosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these data, enzyme-linked immunosorbent assay showed that moderate to severe endometriosis was associated with markedly elevated levels of IL-10 in the peritoneal fluid.
|
12700072 |
2003 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
IL-10 promoter polymorphisms were associated with the production of anti-CA II ab in patients with endometriosis, suggesting a role in the genetic susceptibility for endometriosis.
|
11883743 |
2002 |
|
Endometriosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
IL-10 promoter polymorphisms were associated with the production of anti-CA II ab in patients with endometriosis, suggesting a role in the genetic susceptibility for endometriosis.
|
11883743 |
2002 |