Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both CMS and MS-SCON patients displayed reduced IL-8 and CXCL2 and increased TNF-α levels, while IL-10 and CXCL5 levels were identical among all groups.
|
31556809 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis.
|
31041609 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Correction to: Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis.
|
31115800 |
2019 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In human settings, we show that MGL expression is increased in active MS lesions and on alternatively activated microglia and macrophages which, in turn, induces the secretion of the immunoregulatory cytokine IL-10, underscoring the clinical relevance of this lectin.
|
31248427 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Besides, the levels of anti-inflammatory cytokines include IL-4 and IL-10 was significantly higher in MS patients infected with HP when compared with MS patients seronegative for HP infection.
|
31610314 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elicitation of specific IL-10 production by peptide-specific T cells in MS and NMOSD patients indicates that a key element in antigen specific tolerance is activated with this approach.
|
30962374 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-10 and miR-96 are associated with MS quiescence, however, the lack of a significant correlation between them implicates that the influence of miR-96 may be exhibited through some pathway other than IL-10.
|
31238191 |
2019 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The ability of Breg cells to produce IL-10 was at normal levels in both ON patients with high risk and those with low risk of progression to MS. We found no correlation between Breg cell function and the presence of brain white matter lesions by magnetic resonance imaging or CSF oligoclonal bands indicative of ON patients carrying a higher risk of conversion to MS.
|
30452090 |
2019 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IL4 and IL10 genes harbor important SNPs that may confer MS susceptibility.
|
31264107 |
2019 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we identify an imbalance between the cytokines IFN-γ and IL-10 as a shared T<sub>reg</sub> signature present in patients with multiple sclerosis and under high-salt conditions.
|
30374130 |
2018 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
TLR4 and CD40 co-stimulation synergistically increased the frequency of IL-10-producing but not pro-inflammatory cytokine-producing B cells at MS relapse.
|
29146546 |
2018 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MP treatment induced significant amplification in the transcript levels of iNOS and TNF-α (M1-related markers) in the corpus callosum of the MS mice, whereas no change detected in the expression of IL-10 (M2-related marker) between the groups.
|
30143908 |
2018 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The concentration of sCD27 was higher in the NMO group than in the MS (p = 0.082) and CTL (p = 0.002) groups, and there was a positive correlation with CSF IL-6 (p = 0.000) and a negative correlation with IL-10 (p = 0.073).
|
30423585 |
2018 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cerebrospinal fluid IL-10 as an early stage discriminative marker between multiple sclerosis and neuro-Behçet disease.
|
29625335 |
2018 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Conclusion Peripheral blood CD19<sup>+</sup>CD24<sup>hi</sup>CD38<sup>hi</sup> Breg cell levels and serum IL-10 levels were reduced in MS patients compared with controls, but Breg cell levels were not correlated with MS EDSS score.
|
30025488 |
2018 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Median CSF IL-10 and sIL-2R levels were higher in CNS lymphoma patients than in MS, NMOSD, or TDL patients.
|
28657431 |
2018 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of proinflammatory cytokines (IFNγ, TNF, IL2, and IL22) and molecules related to sustained B-cell activity and lymphoid-neogenesis (CXCL13, CXCL10, LTα, IL6, and IL10) was detected in the meninges and CSF of postmortem MS cases with high levels of meningeal inflammation and GM demyelination.
|
29518260 |
2018 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, a meta-analysis has been performed to assess the relationship between IL-10 gene polymorphisms rs1800896, rs1800871 and rs1800872 with the risk of MS. Nine case-control studies were selected involving 2755 participants.
|
28385181 |
2017 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients.
|
28225209 |
2017 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IFN-β1a decreased IL-17 and increased IL-10 seric levels; IL-17 significantly correlated with MS activity; TGF-β1 activity is titer-dependent, increased levels were associated with IL-17 inhibition; NR patients to IFN-β1a will have initial high IL-17 and low IL-10 and TGF-β seric levels.
|
27306062 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This is the first pharmacological assessment of such a broad range of EAE symptoms, and provides support for IL-10 gene therapy as a clinical strategy for the treatment of multiple sclerosis.
|
27189037 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This was surprising as both TLR3 and IL-10 play protective roles in animal models of MS. Interestingly, combination of TLR3 triggering with the other TLRs, enhanced IL-10 through the modulation of its transcription, via interferon (IFN)-β, but independently of IL-27.
|
28617991 |
2017 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-1β, IL-6, TNF-α, IFN-γ, IL-17, IL-4, and IL-10 levels were higher in progressive MS than in controls.
|
27023227 |
2017 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL-10 -1082 G/G and IL-10 -819 C/C genotypes were more frequent in MS patients than healthy individuals.
|
29067976 |
2017 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional signature of human pro-inflammatory T<sub>H</sub>17 cells identifies reduced IL10 gene expression in multiple sclerosis.
|
29150604 |
2017 |