IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10. 31370884 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Finally, to provide additional potential clinical relevance, we examined the effect of IL-10 on T cell IFN-γ production in an in vivo cecal ligation and puncture model of sepsis using C57 black/J6 female mice. 31501258 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Sepsis increased plasma interleukin-6 (IL-6) and IL-10 and clonidine further increased IL-10 (1.6 ± 0.1 to 3.3 ± 0.7 ng/mL), but not IL-6.Clonidine reduced rectal temperature. 29489737 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Because of B-1a cell loss, Cmtm7-deficient mice produced less IgM and IL-10, and were more susceptible to microbial sepsis. 31081901 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE In particular, IFN-γ as well as IL-10-activated CBMΦ completely fail to increase glycolysis and furthermore show reduced activation of the mTOR pathway, which is important for survival in sepsis. 30976008 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Circulating concentrations of CRP, PCT, interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra) were significantly higher in patients with sepsis, with IL-10 identified as the best biomarker in differentiating sepsis from SIRS. 31125901 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE CMV is reactivated in sepsis and these patients presented a higher risk of developing septic shock and higher mortality rates and our data suggest that IL-10 and NO may be involved in this process. 31227794 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Altogether, AT treatment improved survival, increased IL-10 levels, and mitigated a pro-inflammatory response during sepsis. 30897322 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Interestingly, the most important difference in the production of cytokines and chemokines after in vivo AIM blockade or AIM administration during sepsis was IL-10. 30326743 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE SPIONs also increased the level of interleukin-10 (IL-10) in liver macrophages, while SPIONs's effect on LPS-induced sepsis was abrogated in <i>IL-10<sup>-/-</sup></i> mice, indicating that the protective effect of SPIONs is dependent on IL-10<sup>+</sup> macrophages. 31692534 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Stimulation with S. epidermidis sepsis strains induced higher IL-6 and IL-10 expression than stimulation with colonization strains. 30146415 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE The activation of the TLR4/TLR9/p38 MAPK/STAT3 signal pathway contributes to the production of miR-23b in CLP-induced sepsis. miR-23b inhibitor decreased the number of spleen cells positive by terminal deoxynucleotidyl transferase dUTP nick-end labeling and improved survival. miR-23b inhibitor restored the immunoreactivity by alleviating the development of T-cell exhaustion and producing smaller amounts of immunosuppressive interleukin 10 and interleukin 4 during late sepsis. 29506272 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-<i>α</i> and IL-1<i>β</i> in peritoneal lavage fluid of mice with sepsis. 30538802 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE IL6 had the most sensitivity and IL10 had the most specificity for diagnosis of sepsis. 29239828 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE We therefore conclude that high production of IL-10 by monocytes may, in part, explain the greater propensity for <i>S</i> Choleraesuis to induce human sepsis and that this may be greater in strains such as A50, which induces both high IL-10 production and monocyte survival. 30037797 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Furthermore, we demonstrated that IL-10 reduction of T-cell functionality was associated with increased FOXP3 expression in CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>-</sup> regulatory T cells as observed in sepsis. 29182416 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE We recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic medical records (EMR) according to whether data on PCT, CRP, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IL-22, TNF-α, and IFN-γ levels were available. 30547887 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE A Cox proportional hazards model focussed on the acute phase showed that the above combined score was significantly related with patient prognosis, suggesting that the cytokine network of IL-6, IL-8, MCP-1 and IL-10 could play a pivotal role in the acute phase of sepsis. 30228372 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Circulating IL-10 levels increased significantly after 12 h in the sepsis groups compared with sham animals, while that of the NT and HT groups were comparable. 29505782 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Mice deficient in IL-13-producing cells, including ILC2s, had a survival advantage after sepsis along with decreased morphologic evidence of tissue injury and reduced IL-10 levels in the peritoneal fluid. 29935165 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE These results support that IL-10 drives the molecular path that generates MDSCs and enhances immunosuppression during late sepsis, and inform that targeting this immune repressor path may improve sepsis survival in mice. 30025864 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE A total of 120 consecutive Chinese patients with sepsis were prospectively included, and serum levels of FGF21 and biomarkers such as interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), IL-10, procalcitonin (PCT), C-reactive protein (CRP), and lactate (LAC) were measured within 24 h after intensive care unit admission. 29861384 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE IL-38 administration decreased the inflammatory response, as reflected by lower levels of cytokines and chemokines (including IL-6, TNF-α, interleukin 10, interleukin 17, interleukin 27, CXCL1, and CCL2), and less damage to tissues (including lung, liver, and kidney) in CLP-induced sepsis. 29762676 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE The ablation of G protein-coupled receptor 39 significantly reduced IL-10 production by TC-G 1008 in thioglycollate-induced peritoneal macrophages stimulated with LPS and in the LPS-induced murine model of sepsis. 30053407 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Makino, or C. longa L. in control or sepsis groups in this study, only the influence of IL-10 was consistent in both control and sepsis groups. 29462699 2018