|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating concentrations of CRP, PCT, interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra) were significantly higher in patients with sepsis, with IL-10 identified as the best biomarker in differentiating sepsis from SIRS.
|
31125901 |
2019 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The lower serum levels of IL-10 (SC - 0.330; p 0.022) and TGF-β (SC - 0.612; p < 0.001), and the presence of other systemic infections during pregnancy (SC 0.159; 0.049) explained the higher occurrence of PTB.
|
31677089 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10.
|
31370884 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, to provide additional potential clinical relevance, we examined the effect of IL-10 on T cell IFN-γ production in an in vivo cecal ligation and puncture model of sepsis using C57 black/J6 female mice.
|
31501258 |
2019 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In particular, IFN-γ as well as IL-10-activated CBMΦ completely fail to increase glycolysis and furthermore show reduced activation of the mTOR pathway, which is important for survival in sepsis.
|
30976008 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interestingly, the most important difference in the production of cytokines and chemokines after in vivo AIM blockade or AIM administration during sepsis was IL-10.
|
30326743 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sepsis increased plasma interleukin-6 (IL-6) and IL-10 and clonidine further increased IL-10 (1.6 ± 0.1 to 3.3 ± 0.7 ng/mL), but not IL-6.Clonidine reduced rectal temperature.
|
29489737 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because of B-1a cell loss, Cmtm7-deficient mice produced less IgM and IL-10, and were more susceptible to microbial sepsis.
|
31081901 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
CMV is reactivated in sepsis and these patients presented a higher risk of developing septic shock and higher mortality rates and our data suggest that IL-10 and NO may be involved in this process.
|
31227794 |
2019 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Altogether, AT treatment improved survival, increased IL-10 levels, and mitigated a pro-inflammatory response during sepsis.
|
30897322 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
SPIONs also increased the level of interleukin-10 (IL-10) in liver macrophages, while SPIONs's effect on LPS-induced sepsis was abrogated in <i>IL-10<sup>-/-</sup></i> mice, indicating that the protective effect of SPIONs is dependent on IL-10<sup>+</sup> macrophages.
|
31692534 |
2019 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-<i>α</i> and IL-1<i>β</i> in peritoneal lavage fluid of mice with sepsis.
|
30538802 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Makino, or C. longa L. in control or sepsis groups in this study, only the influence of IL-10 was consistent in both control and sepsis groups.
|
29462699 |
2018 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings indicated that the levels of TNF-α, IL-6, IL-8, PCT, ET-1 and IL-10 were associated with the condition and prognosis of elderly patients with sepsis, and the assessment system for immune levels based on the levels of these indicators was conducive to the stipulation of individualized immune regulation procedure and prognostic evaluation of sepsis.
|
30112039 |
2018 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrated that IL-10 reduction of T-cell functionality was associated with increased FOXP3 expression in CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>-</sup> regulatory T cells as observed in sepsis.
|
29182416 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results support that IL-10 drives the molecular path that generates MDSCs and enhances immunosuppression during late sepsis, and inform that targeting this immune repressor path may improve sepsis survival in mice.
|
30025864 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We therefore conclude that high production of IL-10 by monocytes may, in part, explain the greater propensity for <i>S</i> Choleraesuis to induce human sepsis and that this may be greater in strains such as A50, which induces both high IL-10 production and monocyte survival.
|
30037797 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A Cox proportional hazards model focussed on the acute phase showed that the above combined score was significantly related with patient prognosis, suggesting that the cytokine network of IL-6, IL-8, MCP-1 and IL-10 could play a pivotal role in the acute phase of sepsis.
|
30228372 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The activation of the TLR4/TLR9/p38 MAPK/STAT3 signal pathway contributes to the production of miR-23b in CLP-induced sepsis. miR-23b inhibitor decreased the number of spleen cells positive by terminal deoxynucleotidyl transferase dUTP nick-end labeling and improved survival. miR-23b inhibitor restored the immunoreactivity by alleviating the development of T-cell exhaustion and producing smaller amounts of immunosuppressive interleukin 10 and interleukin 4 during late sepsis.
|
29506272 |
2018 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Circulating IL-10 levels increased significantly after 12 h in the sepsis groups compared with sham animals, while that of the NT and HT groups were comparable.
|
29505782 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-38 administration decreased the inflammatory response, as reflected by lower levels of cytokines and chemokines (including IL-6, TNF-α, interleukin 10, interleukin 17, interleukin 27, CXCL1, and CCL2), and less damage to tissues (including lung, liver, and kidney) in CLP-induced sepsis.
|
29762676 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic medical records (EMR) according to whether data on PCT, CRP, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IL-22, TNF-α, and IFN-γ levels were available.
|
30547887 |
2018 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mice deficient in IL-13-producing cells, including ILC2s, had a survival advantage after sepsis along with decreased morphologic evidence of tissue injury and reduced IL-10 levels in the peritoneal fluid.
|
29935165 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The ablation of G protein-coupled receptor 39 significantly reduced IL-10 production by TC-G 1008 in thioglycollate-induced peritoneal macrophages stimulated with LPS and in the LPS-induced murine model of sepsis.
|
30053407 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
A total of 120 consecutive Chinese patients with sepsis were prospectively included, and serum levels of FGF21 and biomarkers such as interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), IL-10, procalcitonin (PCT), C-reactive protein (CRP), and lactate (LAC) were measured within 24 h after intensive care unit admission.
|
29861384 |
2018 |